This study aims to investigate the multi-objective optimization method for liquid cooling plates in automotive power batteries. The response surface method and NSGA-II were combined to optimize the temperature of the battery system under liquid-cooled conditions and the internal pressure of the liquid-cooled plate. The optimal Latin hypercube sampling method was used for sampling, with the flow channel parameters of the liquid-cooled plate and the cooling fluid inlet flow rate as design variables and the maximum temperature of the battery system and the maximum internal pressure of the liquid-cooled plate as target functions. The response surface model was fitted, and the Pareto solution set for the target to be optimized was obtained using NSGA-II. The LINMAP decision-making algorithm was employed to obtain the optimal solution, which is a maximum temperature of 37.25 degrees C for the battery and a maximum pressure of 63.3 Pa for the liquid-cooled plate.