Dimethylamino-Functionalized BODIPY Nanoparticle Enhances Near-Infrared Fluorescence Imaging and Photothermal Therapy

被引：2
作者：
Wang, Xin [1 ]
Zhao, Xingyu [2 ,3 ]
Qi, Huixuan [2 ,3 ]
Yuan, Chunyu [4 ,5 ]
Qu, Ruobing [2 ,3 ]
Lin, Wenhai [2 ,3 ]
Li, Min [4 ,5 ,6 ]
机构：
[1] First Hosp Jilin Univ, Gen Surg Ctr, Dept Thyroid Surg, Changchun 130021, Peoples R China
[2] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Biomed Polymers Lab, Suzhou 215123, Peoples R China
[3] Soochow Univ, State Key Lab Radiat Med & Protect, Suzhou 215123, Peoples R China
[4] Soochow Univ, Affliated Hosp 4, Suzhou Dushu Lake Hosp, Dept Dermatol, Suzhou 215125, Jiangsu, Peoples R China
[5] Soochow Univ, Med Ctr, Suzhou 215125, Jiangsu, Peoples R China
[6] Soochow Univ, Affiliated Hosp 1, Dept Dermatol, Suzhou 215006, Jiangsu, Peoples R China
来源：
ACS APPLIED NANO MATERIALS | 2024年 / 7卷 / 22期
关键词：
boron dipyrromethene; near-infrared fluorescence imaging; photothermal therapy; high signal-to-noise ratio; pH-responsive; PACLITAXEL; PERMEABILITY; DELIVERY; AGENT;
D O I：
10.1021/acsanm.4c05370
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Organic dyes have been widely used in bioimaging, molecular probes, imaging in vivo, and phototherapy. However, it is still a major challenge to improve the imaging and therapeutic properties of organic dyes. In this work, boron dipyrromethene (BODIPY) nanoparticles (NPs) were synthesized with poly(ethylene glycol)2k-block-poly(d,l-lactide)2k (PEG-PLA) NPs for tumor microenvironment response, near-infrared fluorescence (NIRF) imaging with a high signal-to-noise ratio (SNR), and photothermal therapy (PTT). The absorption and fluorescence spectra of the obtained BDP changed as the pH decreased. The introduction of a dimethylamino group enhanced the photothermal conversion efficiency and imaging capability of BODIPY-loaded PEG-PLA NPs (BDP NPs). After injection into mice, these NPs showed excellent photothermal efficacy toward hepatoma and papillary thyroid cancer. Additionally, BDP NPs could be used for NIRF imaging with a high SNR after BODIPY was modified with a dimethylamino group. This work highlights that molecular engineering can enhance the luminescence and photothermal properties of dyes and that BDP NPs are excellent theranostic agents.
引用
收藏
页码：26077 / 26085
页数：9
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