Mamastrovirus spike protein: Sequence and structural characterization as a basis for understanding cross-species transmission

被引:1
|
作者
Wang, Yong [1 ]
Guo, Xu [1 ]
Chang, Shengbo [3 ]
Zhao, Liang [4 ]
Li, Aolin [1 ]
Liu, Xunbi [1 ]
Ma, Hongfu [1 ]
Li, Yongdong [2 ]
机构
[1] Anhui Agr Univ, Coll Anim Sci & Technol, Hefei, Peoples R China
[2] Ningbo Municipal Ctr Dis Control & Prevent, Municipal Key Lab Virol, Ningbo, Peoples R China
[3] Northwestern Polytech Univ, Dept Ind Engn, Xian 710071, Peoples R China
[4] Anim Husb Dev Ctr Luan, Luan, Peoples R China
关键词
Astrovirus; Mamastrovirus; Spike; Cross-species transmission; Structure analysis; GENETIC-HETEROGENEITY; RECOMBINATION; ALGORITHM; SELECTION; MULTIPLE; BIOLOGY;
D O I
10.1016/j.ijbiomac.2024.137366
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Astroviruses (AstVs) are notable for their propensity for cross-species transmission; however, the molecular determinants underlying this phenomenon remain poorly understood. The spike protein, which is responsible for host cell entry and is a major antigenic determinant, is hypothesized to play a pivotal role. In this study, we observed high sequence variability in the spike region of AstV. Structural analyses have revealed variability, arising from diverse evolutionary relationships, among AstVs of the same host origin. AstV spike proteins can be categorized into six groups, each of which encompasses AstVs from diverse hosts that exhibit high degrees of structural similarity. These six groups correspond to branches observed in the phylogenetic tree. Notably, the spike surface-exposed loops emerged as focal hotspots for B-cell epitopes across groups, with sequence variability that may contribute to immune evasion upon host switching. Differences in the spike structures of AstVs infecting the same host raise the possibility of distinct tissue tropisms and corresponding clinical manifestations. Collectively, our findings provide insights into the roles of spike protein similarities and immune epitope diversity in driving AstV cross-species transmission. Understanding these molecular mechanisms is crucial to predicting and mitigating the emergence of novel AstV strains.
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页数:10
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