A mild and convenient protocol for the synthesis of quinoxalin-2(1H)-ones and benzimidazoles

被引：0
|
作者：
Luo, Zhenbiao [1 ]
Wang, Mingyuan [1 ]
Jiang, Guidong [1 ]
Wang, Xinye [1 ]
Zhao, Liang [1 ]
Hu, Zhihui [1 ]
Li, Honghe [1 ]
Ji, Qing [1 ]
机构：
[1] Moutai Inst, Dept Brewing Engn, Renhuai 564507, Guizhou, Peoples R China
来源：
RSC ADVANCES | 2024年 / 14卷 / 48期
基金：
中国国家自然科学基金;
关键词：
QUINOXALINE DERIVATIVES; BIOLOGICAL EVALUATION; CYCLIZATION; EFFICIENT; ANILINES; DESIGN;
D O I：
10.1039/d4ra06887d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We present a mild and simple method for the cyclization of N-protected o-phenylenediamines with carbonyl compounds in the presence of trifluoroacetic acid. This method reliably provides various substrates of benzimidazoles and quinoxalin-2(1H)-ones, with all reactions conducted at room temperature, demonstrating excellent substrate adaptability and a broad substrate scope.
引用
收藏
页码：35386 / 35390
页数：5
相关论文
共 50 条
  • [21] Photoinduced Dehydrogenative Amination of Quinoxalin-2(1H)-ones with Air as an Oxidant
    Jiao, Haoran
    Jing, Yue
    Niu, Kaikai
    Song, Hongjian
    Liu, Yuxiu
    Wang, Qingmin
    JOURNAL OF ORGANIC CHEMISTRY, 2024, 89 (08): : 5371 - 5381
  • [22] Photoinduced rapid Chloropropylation of Quinoxalin-2(1H)-ones with Cyclopropane and HCl
    Liang, Chenfeng
    Wang, Zhihao
    Chen, Qing
    Wu, Jirong
    Zhang, Pengfei
    Shen, Jiabin
    MOLECULAR CATALYSIS, 2024, 558
  • [23] Merging Quinoxalin-2(1H)-ones Excitation with Cobaloxime Catalysis: C3 Alkylation of Quinoxalin-2(1H)-ones with Unactivated Alkyl Iodides and Carboxylic Acids under Light
    Cao, Shuo
    Chen, Jia-Xin
    Zhang, Xiu-Li
    Song, Xian
    Song, Wen-Yu
    Wu, Yu-Sheng
    Zhang, Yan-Hui
    Liu, Zan
    ORGANIC LETTERS, 2024, : 5833 - 5838
  • [24] Photoinduced Decarboxylative C3-H Alkylation of Quinoxalin-2(1H)-ones
    Bisoyi, Akash
    Tripathy, Alisha Rani
    Yedase, Girish Suresh
    Sinu, P. Shifana
    Choudhury, Udita
    Yatham, Veera Reddy
    JOURNAL OF ORGANIC CHEMISTRY, 2023, 88 (04): : 2631 - 2641
  • [25] Electro-oxidative C-H azolation of quinoxalin-2(1H)-ones
    Niu, Kaikai
    Ding, Ling
    Zhou, Pan
    Hao, Yanke
    Liu, Yuxiu
    Song, Hongjian
    Wang, Qingmin
    GREEN CHEMISTRY, 2021, 23 (09) : 3246 - 3249
  • [26] Electro-reductive C-H cyanoalkylation of quinoxalin-2(1H)-ones
    Ling Ding
    Kaikai Niu
    Yuxiu Liu
    Qingmin Wang
    Chinese Chemical Letters, 2022, 33 (08) : 4057 - 4060
  • [27] Electro-reductive C-H cyanoalkylation of quinoxalin-2(1H)-ones
    Ding, Ling
    Niu, Kaikai
    Liu, Yuxiu
    Wang, Qingmin
    CHINESE CHEMICAL LETTERS, 2022, 33 (08) : 4057 - 4060
  • [28] Three-Component Reactions of Quinoxalin-2(1H)-ones: Recent Advances
    Wang, Ke-Li
    Ji, Hong-Tao
    Ou, Li-Juan
    He, Wei-Min
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2023,
  • [29] Photoinitiated Deaminative Alkylation of Quinoxalin-2(1H)-ones via Electron Catalysis
    Deng, Yangling
    Cheng, Xiya
    Tan, Heping
    He, Yuxuan
    Zhang, Changmei
    Qiu, Guanyinsheng
    Zheng, Danqing
    ADVANCED SYNTHESIS & CATALYSIS, 2023, 365 (06) : 865 - 870
  • [30] Visible light photoredox-catalyzed phosphorylation of quinoxalin-2(1H)- ones
    Kim, Yubin
    Kim, Dae Young
    TETRAHEDRON LETTERS, 2018, 59 (25) : 2443 - 2446
12345