A mild and convenient protocol for the synthesis of quinoxalin-2(1H)-ones and benzimidazoles

被引：0
作者：
Luo, Zhenbiao [1 ]
Wang, Mingyuan [1 ]
Jiang, Guidong [1 ]
Wang, Xinye [1 ]
Zhao, Liang [1 ]
Hu, Zhihui [1 ]
Li, Honghe [1 ]
Ji, Qing [1 ]
机构：
[1] Moutai Inst, Dept Brewing Engn, Renhuai 564507, Guizhou, Peoples R China
来源：
RSC ADVANCES | 2024年 / 14卷 / 48期
基金：
中国国家自然科学基金;
关键词：
QUINOXALINE DERIVATIVES; BIOLOGICAL EVALUATION; CYCLIZATION; EFFICIENT; ANILINES; DESIGN;
D O I：
10.1039/d4ra06887d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We present a mild and simple method for the cyclization of N-protected o-phenylenediamines with carbonyl compounds in the presence of trifluoroacetic acid. This method reliably provides various substrates of benzimidazoles and quinoxalin-2(1H)-ones, with all reactions conducted at room temperature, demonstrating excellent substrate adaptability and a broad substrate scope.
引用
收藏
页码：35386 / 35390
页数：5
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