Recent Advances in Degradable Biomedical Polymers for Prevention, Diagnosis and Treatment of Diseases

被引:5
|
作者
Zhang, Siting [1 ]
Fang, Huapan [1 ,2 ]
Tian, Huayu [1 ]
机构
[1] Xiamen Univ, Coll Chem & Chem Engn, State Key Lab Phys Chem Solid Surfaces, Innovat Lab Sci & Technol Energy Mat Fujian Prov I, Xiamen 361005, Peoples R China
[2] Xiamen Univ, Shenzhen Res Inst, Shenzhen 518000, Peoples R China
基金
中国国家自然科学基金;
关键词
TARGETED DRUG-DELIVERY; POLYLACTIC ACID PLA; PLGA-BASED NANOPARTICLES; GROWTH-FACTOR DELIVERY; BIODEGRADABLE POLYMERS; IN-VITRO; CATIONIC MICELLE; IMMUNE-RESPONSE; WOUND DRESSINGS; NATURAL POLYMER;
D O I
10.1021/acs.biomac.4c01193
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Biomedical polymers play a key role in preventing, diagnosing, and treating diseases, showcasing a wide range of applications. Their unique advantages, such as rich source, good biocompatibility, and excellent modifiability, make them ideal biomaterials for drug delivery, biomedical imaging, and tissue engineering. However, conventional biomedical polymers suffer from poor degradation in vivo, increasing the risks of bioaccumulation and potential toxicity. To address these issues, degradable biomedical polymers can serve as an alternative strategy in biomedicine. Degradable biomedical polymers can efficiently relieve bioaccumulation in vivo and effectively reduce patient burden in disease management. This review comprehensively introduces the classification and properties of biomedical polymers and the recent research progress of degradable biomedical polymers in various diseases. Through an in-depth analysis of their classification, properties, and applications, we aim to provide strong guidance for promoting basic research and clinical translation of degradable biomedical polymers.
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页码:7015 / 7057
页数:43
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