Evaluating Ocular Blood Flow in Diabetic Macular Edema using Three-dimensional Pseudocontinuous Arterial Spin Labeling

被引：0
作者：
Sun J. [1 ]
Wang H. [2 ]
Wang Y.-L. [1 ]
机构：
[1] Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing
[2] Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing
来源：
Current Medical Imaging | 2024年 / 20卷
基金：
中国国家自然科学基金;
关键词：
Arterial spin labeling; Diabetes; Diabetic macular edema; Magnetic resonance imaging; Ocular blood flow; Retinopathy;
D O I：
10.2174/0115734056307305240403060707
中图分类号：
学科分类号：
摘要：
Background: Alterations in ocular blood flow play an important role in the pathogenesis of diabetic macular edema; however, this remains unclear. Objectives: This study aimed to investigate ocular blood flow in eyes with or without diabetic macular edema using arterial spin labeling. Methods: This cross-sectional study included 118 eyes of 65 patients with diabetic retinopathy analyzed between November 2018 and December 2019. We included a total of 53 eyes without diabetic macular edema (mean [SD] age, 57.83 [7.23] years; 29 men [54.7%]) and 65 eyes with diabetic macular edema (mean [SD] age, 60.11 [7.63] years; 38 men [58.5%]). Using a 3.0-T magnetic resonance imaging, participants were imaged with arterial spin labeling with multiple post-labeling delays. Results: The mean ocular blood flow at post-labeling delays of 1.5 and 2.5 s was significantly lower in eyes with diabetic macular edema among patients with diabetic retinopathy compared with the remaining subgroups (P=0.022 and P <0.001, respectively). The mean ocular blood flow exhibited a significant decrease in eyes with diabetic macular edema when the post-labeling delay was set at 2.5 s in the nonproliferative and proliferative diabetic retinopathy groups, compared with the remaining subgroups (P=0.005 and P=0.002, respectively). The cutoff points of ocular blood flow at post-labeling delays of 1.5 s and 2.5 s were 9.40 and 11.10 mL/100 g/min, respectively. Conclusion: Three-dimensional pseudocontinuous arterial spin labeling can identify differences in the ocular blood flow of patients with diabetic eyes with and without diabetic macular edema. © 2024 The Author(s).
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