Comparative Study on the Antioxidative Effects and α-Glucosidase Inhibitory Potential In Vitro among Ellagic Acid and Its Metabolites Urolithins

被引：4
作者：
Li, Zhao-Rong [1 ,2 ]
Jia, Rui-Bo [1 ,2 ,3 ]
Mo, Yurong [3 ]
Wang, Haozheng [3 ]
Luo, Donghui [2 ,3 ]
Zhou, Chunxia [3 ]
Zhao, Mouming [1 ,2 ]
机构：
[1] South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Peoples R China
[2] Chaozhou Branch Chem & Chem Engn Guangdong Lab, Chaozhou 521000, Peoples R China
[3] Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2024年 / 72卷 / 48期
关键词：
ellagic acid; urolithins; biological activities; structure-activity relationship; HEALTH; ELLAGITANNINS; FLAVONOIDS;
D O I：
10.1021/acs.jafc.4c06542
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
The current study compared the radical scavenging and alpha-glucosidase inhibition potentials of ellagic acid (EA) and its metabolites, urolithins (Uros), and further explored the structure-activity relationship. The outcomes indicated that urolithin M5 (Uro-M5), EA, and urolithin M6 (Uro-M6) exhibited superior 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity; EA and urolithin D (Uro-D) expressed better ABTS scavenging ability, and EA and Uro-M5 showed preferable alpha-glucosidase inhibition activity. The results of CD spectra and fluorescence spectral analysis explained the interaction between Uros and alpha-glucosidase. Correlation analysis indicated that hydroxyl groups were crucial for the antioxidative effect, while C-8 OH contributed greatly to the alpha-glucosidase inhibition activity. Quantum mechanical analysis showed that both EA and Uros exhibited strong electrophilic properties. These comparative results showed a biological discrepancy between Uros and provided essential information for exploring the bioactive application of EA as a functional ingredient or dietary supplement.
引用
收藏
页码：26711 / 26721
页数：11
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