Expanding the Genetic Code of Bioelectrocatalysis and Biomaterials

被引：5

作者：

Chemla, Yonatan ^{[1
,3
]}

Kaufman, Federico ^{[2
]}

Amiram, Miriam ^{[2
]}

Alfonta, Lital ^{[1
]}

机构：

[1] Ben Gurion Univ Negev, Dept Life Sci, IL-8410501 Beer Sheva, Israel

[2] Ben Gurion Univ Negev, Avram & Stella Goldstein Goren Dept Biotechnol Eng, IL-8410501 Beer Sheva, Israel

[3] MIT, Synthet Biol Ctr, Dept Biol Engn, Cambridge, MA USA

来源：

CHEMICAL REVIEWS | 2024年 / 124卷 / 20期

基金：

以色列科学基金会;

关键词：

SITE-SPECIFIC INCORPORATION; UNNATURAL AMINO-ACIDS; ELASTIN-LIKE POLYPEPTIDES; DIRECT ELECTRON-TRANSFER; TRANSFER-RNA SYNTHETASE; COLI RIBONUCLEOTIDE REDUCTASE; COLLAGEN TRIPLE HELICES; IN-VIVO INCORPORATION; PROXIMAL HEME LIGAND; MORI SILK FIBROIN;

D O I：

10.1021/acs.chemrev.4c00077

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Genetic code expansion is a promising genetic engineering technology that incorporates noncanonical amino acids into proteins alongside the natural set of 20 amino acids. This enables the precise encoding of non-natural chemical groups in proteins. This review focuses on the applications of genetic code expansion in bioelectrocatalysis and biomaterials. In bioelectrocatalysis, this technique enhances the efficiency and selectivity of bioelectrocatalysts for use in sensors, biofuel cells, and enzymatic electrodes. In biomaterials, incorporating non-natural chemical groups into protein-based polymers facilitates the modification, fine-tuning, or the engineering of new biomaterial properties. The review provides an overview of relevant technologies, discusses applications, and highlights achievements, challenges, and prospects in these fields.

引用

页码：11187 / 11241

页数：55

共 481 条

[81] Addition of p-azido-L-phenylaianine to the genetic code of Escherichia coli [J].