Progress in Understanding the Relationship between Human Milk Oligosaccharides and Infant Gut Microbiota

被引:1
作者
Yuan H. [1 ]
Xun Y. [2 ]
Pu X. [1 ]
Zhu H. [2 ]
Wang S. [1 ,2 ]
机构
[1] College of Food Science and Biology, Hebei University of Science and Technology, Shijiazhuang
[2] Shijiazhuang Junlebao Dairy Co., Ltd., Shijiazhuang
来源
Shipin Kexue/Food Science | 2021年 / 42卷 / 13期
关键词
Compositional structure; Correlation; Gut microbiome; Human milk oligosaccharides; Infant; Metabolites;
D O I
10.7506/spkx1002-6630-20200605-072
中图分类号
学科分类号
摘要
Breast milk is rich in human milk oligosaccharides (HMOs), which are prebiotics that can stimulate the growth of beneficial bacteria in the neonatal intestine. At present, the oligosaccharides allowed to be added to infant formula in China are structurally different from HMOs so that they cannot simulate some structure-specific effects of HMOs. This review describes the composition, structure and content of HMOs in breast milk, focusing on the relationship between HMOs as well as their metabolites and the infant intestinal microbiota. Finally, the beneficial effects of feeding infant formula with HMOs on the infant intestinal flora are discussed, which will provide theoretical support for promoting the application of HMOs in infant formula foods. © 2021, China Food Publishing Company. All right reserved.
引用
收藏
页码:319 / 325
页数:6
相关论文
共 59 条
[1]  
ELISON E, VIGSNAES L K, KROGSGAARD L R, Et al., Oral supplementation of healthy adults with 2'-O-fucosyllactose and lacto-N-neotetraose is well tolerated and shifts the intestinal microbiota, British Journal of Nutrition, 116, 8, pp. 1356-1368, (2016)
[2]  
MIQDADY M, MISTARIHI J A, AZAZ A, Et al., Prebiotics in the infant microbiome: the past, present, and future, Pediatric Gastroenterology, Hepatology & Nutrition, 23, 1, pp. 1-14, (2020)
[3]  
HIRVONEN J, SALLI K, PUTAALA H, Et al., Selective utilization of human milk oligosaccharides 2'-FL and 3'-FL by probiotic bacteria resulting in different metabolite production by these bacteria, Current Developments in Nutrition, 3, (2019)
[4]  
RAY C, KERKETTA J A, RAO S, Et al., Human milk oligosaccharides:the journey ahead, International Journal of Pediatrics, (2019)
[5]  
BOREWICZ K, GU F, SACCENTI E, Et al., Correlating infant faecal microbiota composition and human milk oligosaccharide consumption by microbiota of one-month old breastfed infants, Molecular Nutrition & Food Research, (2019)
[6]  
DOTZ V, RUDLOFF S, MEYER C, Et al., Metabolic fate of neutral human milk oligosaccharides in exclusively breast-fed infants, Molecular Nutrition & Food Research, 59, 2, pp. 355-364, (2015)
[7]  
RUIZMOYANO S, TOTTEN S M, GARRIDO D, Et al., Variation in consumption of human milk oligosaccharides by infant gut-associated strains of Bifidobacterium breve, Applied and Environmental Microbiology, 79, 19, pp. 6040-6049, (2013)
[8]  
VANDENPLAS Y, BERGER B, CARNIELLI V P, Et al., Human milk oligosaccharides: 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose(LNnT) in Infant formula, Nutrients, 10, 9, pp. 183-198, (2018)
[9]  
MORRIN S T, IRWIN J A, HICKEY R M., The role of milk oligosaccharides in host-microbial interactions and their defensive function in the gut, Diet, microbiome and health, pp. 199-236, (2018)
[10]  
SALAMONE M, NARDO D., Effects of human milk oligosaccharides(HMOs) on gastrointestinal health, Frontiers in Bioscience, 12, 1, pp. 183-198, (2020)