Noncanonical Amino Acid Incorporation in Animals and Animal Cells

被引：1

作者：

Kim, Joo-Chan ^{[1
]}

Kim, Youjin ^{[1
]}

Cho, Suho ^{[1
]}

Park, Hee-Sung ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem, Daejeon 34141, South Korea

来源：

CHEMICAL REVIEWS | 2024年 / 124卷 / 22期

基金：

新加坡国家研究基金会;

关键词：

TRANSFER-RNA SYNTHETASE; SITE-SPECIFIC INCORPORATION; NEWLY SYNTHESIZED PROTEINS; GENETIC-CODE EXPANSION; IN-VIVO INCORPORATION; LEUCYL-TRANSFER-RNA; MAMMALIAN-CELLS; CAENORHABDITIS-ELEGANS; ESCHERICHIA-COLI; OPTICAL CONTROL;

D O I：

10.1021/acs.chemrev.3c00955

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Noncanonical amino acids (ncAAs) are synthetic building blocks that, when incorporated into proteins, confer novel functions and enable precise control over biological processes. These small yet powerful tools offer unprecedented opportunities to investigate and manipulate various complex life forms. In particular, ncAA incorporation technology has garnered significant attention in the study of animals and their constituent cells, which serve as invaluable model organisms for gaining insights into human physiology, genetics, and diseases. This review will provide a comprehensive discussion on the applications of ncAA incorporation technology in animals and animal cells, covering past achievements, current developments, and future perspectives.

引用

页码：12463 / 12497

页数：35

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