Surface PEGylation of Poly(Ethylenimine) dendrimers grafted magnetic nanoparticles as a pH and magnetic targeting responsive system for Cytarabine drug delivery

被引：2
|
作者：
Mashak, Saeed Falah [1 ]
Moniri, Elham [1 ]
Azarakhshi, Fatemeh [1 ]
Shahsavari, Shadab [2 ]
Fard, Niloufar Torabi [3 ]
机构：
[1] Islamic Azad Univ, Dept Chem, Varamin Pishva Branch, Varamin, Iran
[2] Islamic Azad Univ, Dept Chem Engn, Varamin Pishva Branch, Varamin, Iran
[3] Islamic Azad Univ, Dept Chem, Cent Tehran Branch, Tehran, Iran
来源：
CHEMICAL PHYSICS LETTERS | 2024年 / 857卷
关键词：
PEGylation; Poly (Ethylenimine) dendrimer; Drug delivery; Cytarabine; IN-VITRO RELEASE; TRANSPORT MECHANISMS; HYDROGEL; ADSORPTION; KINETICS; CHITOSAN; REMOVAL; POLYMER;
D O I：
10.1016/j.cplett.2024.141722
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A pH and magnetically dual responsive platform was synthesized by PEGylation of poly (ethylenimine) dendrimers grafted magnetic nanoparticles for targeted cytarabine delivery. Characterization techniques confirmed the platform structure and properties. Optimal drug adsorption occurred at pH 8, with an adsorbent dosage of 0.01 g, and 60 min of contact time at 298 K. Pseudo-second-order kinetic and Langmuir isotherm models best fit the adsorption data. The thermodynamic data shows that drug adsorption is a favorable and spontaneous process. Drug release rates were 61.45 % and 21.92 % at pH 5.6 and 7.4 over 6 h. The release kinetics followed Korsmeyer-Peppas model, showing non-Fickian behavior.
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页数：11
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