Exploring the Role of Poly (N-vinyl pyrrolidone) in Drug Delivery

被引:1
|
作者
Mikayilov, E. [1 ]
Tagiyev, D. [1 ]
Zeynalov, N. [1 ]
Tagiyev, Sh. [2 ]
机构
[1] Minist Sci & Educ Republ Azerbaijan, Dept Nanostruct Met Polymer Catalysts, Inst Catalysis & Inorgan Chem, Baku, Azerbaijan
[2] Azerbaijan Med Univ, Dept Oncol, Baku, Azerbaijan
关键词
nanoparticles; hydrogels; computational modeling; polyvinylpyrrolidone (PVP); drug delivery; SOLID DISPERSIONS; COMPOSITE MICROPARTICLES; NANOFIBROUS MEMBRANE; HYDROGEL MEMBRANES; PHYSICAL STABILITY; PVP; MICROSPHERES; RELEASE; COPRECIPITATION; MATS;
D O I
10.15255/CABEQ.2024.2331
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Polyvinylpyrrolidone (PVP) is widely recognized for its hydrophilic properties, making it essential in pharmaceutical and biomedical industries as a carrier material. This review examines PVP-enriched delivery systems, emphasizing their capacity to integrate diverse active agents from both organic and synthetic sources. The versatility of PVP is showcased through its use in different formulations, such as microparticles, nanoparticles, fibrous structures, hydrogels, and tablets, which emphasize its potential in innovative drug delivery mechanisms. The review thoroughly examines the customized morphologies for specific PVP-drug combinations, detailing the active agents, methodologies, and processing parameters used. It discusses the advantages and challenges of these systems, underscoring the polymer's significant role in novel pharmaceutical product development. Overall, this detailed analysis confirms PVP's critical position in advancing drug delivery technologies, showcasing its multifaceted applications and potential for pioneering new treatments.
引用
收藏
页码:185 / 196
页数:12
相关论文
共 50 条
  • [1] The Use of Poly(N-vinyl pyrrolidone) in the Delivery of Drugs: A Review
    Franco, Paola
    De Marco, Iolanda
    POLYMERS, 2020, 12 (05)
  • [2] TACTICITY OF POLY(N-VINYL PYRROLIDONE)
    CHENG, HN
    SMITH, TE
    VITUS, DM
    JOURNAL OF POLYMER SCIENCE PART C-POLYMER LETTERS, 1981, 19 (01) : 29 - 31
  • [3] Immobilization of Lipase on Poly(N-Vinyl Pyrrolidone)
    T. A. Kovaleva
    A. S. Belenova
    G. V. Shatalov
    Bulletin of Experimental Biology and Medicine, 2011, 151 : 415 - 417
  • [4] CONFORMATIONAL CHARACTERISTICS OF POLY(N-VINYL PYRROLIDONE)
    TONELLI, AE
    POLYMER, 1982, 23 (05) : 676 - 680
  • [5] Immobilization of Lipase on Poly(N-Vinyl Pyrrolidone)
    Kovaleva, T. A.
    Belenova, A. S.
    Shatalov, G. V.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2011, 151 (04) : 415 - 417
  • [6] Crosslinking of poly(N-vinyl pyrrolidone-co-n-butyl methacrylate) copolymers for controlled drug delivery
    Farhat Huma
    Zareen Akhter
    Tariq Yasin
    M. Zafar-uz-Zaman
    Abdul Manan
    Polymer Bulletin, 2014, 71 : 433 - 451
  • [7] Crosslinking of poly(N-vinyl pyrrolidone-co-n-butyl methacrylate) copolymers for controlled drug delivery
    Huma, Farhat
    Akhter, Zareen
    Yasin, Tariq
    Zafar-uz-Zaman, M.
    Manan, Abdul
    POLYMER BULLETIN, 2014, 71 (02) : 433 - 451
  • [8] Oligonucleotides-Decorated-Poly(N-vinyl pyrrolidone) Nanogels for Gene Delivery
    Dispenza, Clelia
    Adamo, Giorgia
    Sabatino, Maria Antonietta
    Grimaldi, Natascia
    Bulone, Donatella
    Bondi, Maria Luisa
    Rigogliuso, Salvatrice
    Ghersi, Giulio
    JOURNAL OF APPLIED POLYMER SCIENCE, 2014, 131 (02)
  • [9] Pyrene-tagged poly(N-vinyl pyrrolidone) as efficient nano-carrier for anticancer drug delivery
    Mitra, Kheyanath
    Maity, Swapan
    Hajra, Archismita
    Singh, Shikha
    Mondal, Sourov
    Singh, Jaydeep
    Maiti, Pralay
    Ray, Biswajit
    INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 2024, 73 (07) : 533 - 543
  • [10] THETA TEMPERATURE OF POLY(N-VINYL PYRROLIDONE) IN WATER
    SAKELLARIOU, P
    POLYMER, 1992, 33 (06) : 1339 - 1342