Recent progress in scale-up integration of microfluidic droplet generators

被引：0
作者：
Deng C. [1 ]
Wang W. [1 ,2 ]
Xie R. [1 ,2 ]
Ju X. [1 ,2 ]
Liu Z. [1 ,2 ]
Chu L. [1 ,2 ]
机构：
[1] School of Chemical Engineering, Sichuan University, Chengdu
[2] State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu
来源：
Huagong Xuebao/CIESC Journal | 2021年 / 72卷 / 12期
关键词：
Distribution network; Integration; Microchannels; Microfluidics; Scale-up;
D O I：
10.11949/0438-1157.20210921
中图分类号：
学科分类号：
摘要：
Compared with conventional emulsification method, droplet microfluidics can controllably prepare monodisperse droplet templates in microchannels for synthesis of various functional microspheres, and is widely used in a lot of fields such as biological, medical, pharmaceutical and environmental engineering. Due to the low production rate of a single microfluidic droplet generator, scale-up integration of microfluidic droplet generators has become the technical difficulty to widespread utilization at the industrial scale. This paper reviews recent progress in scale-up integration of microfluidic droplet generators. Scale-up integration strategies for different types of microfluidic droplet generators, including droplet generators based on shear force, interfacial tension and passive break-up mechanisms, are mainly introduced. © 2021, Editorial Board of CIESC Journal. All right reserved.
引用
收藏
页码：5965 / 5974
页数：9
相关论文
共 73 条
[1]  
Utech S, Prodanovic R, Mao A S, Et al., Microfluidic generation of monodisperse, structurally homogeneous alginate microgels for cell encapsulation and 3D cell culture, Advanced Healthcare Materials, 4, 11, pp. 1628-1633, (2015)
[2]  
Hou Y, Xie W Y, Achazi K, Et al., Injectable degradable PVA microgels prepared by microfluidic technology for controlled osteogenic differentiation of mesenchymal stem cells, Acta Biomaterialia, 77, pp. 28-37, (2018)
[3]  
Yu D, Dong Z Y, Lim H, Et al., Microfluidic preparation, shrinkage, and surface modification of monodispersed alginate microbeads for 3D cell culture, RSC Advances, 9, 20, pp. 11101-11110, (2019)
[4]  
Wang Q, Qian K, Liu S, Et al., X-ray visible and uniform alginate microspheres loaded with in situ synthesized BaSO<sub>4</sub> nanoparticles for in vivo transcatheter arterial embolization, Biomacromolecules, 16, 4, pp. 1240-1246, (2015)
[5]  
Beh C W, Fu Y L, Weiss C R, Et al., Microfluidic-prepared, monodisperse, X-ray-visible, embolic microspheres for non-oncological embolization applications, Lab on a Chip, 20, 19, pp. 3591-3600, (2020)
[6]  
Han Y, Yang J L, Zhao W W, Et al., Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis, Bioactive Materials, 6, 10, pp. 3596-3607, (2021)
[7]  
Zhao Z Y, Wang Z, Li G, Et al., Injectable microfluidic hydrogel microspheres for cell and drug delivery, Advanced Functional Materials, 31, 31, (2021)
[8]  
Madrigal J L, Stilhano R S, Siltanen C, Et al., Microfluidic generation of alginate microgels for the controlled delivery of lentivectors, Journal of Materials Chemistry B, 4, 43, pp. 6989-6999, (2016)
[9]  
Zhao X, Liu Y, Yu Y, Et al., Hierarchically porous composite microparticles from microfluidics for controllable drug delivery, Nanoscale, 10, 26, pp. 12595-12604, (2018)
[10]  
He F, Zhang M J, Wang W, Et al., Designable polymeric microparticles from droplet microfluidics for controlled drug release, Advanced Materials Technologies, 4, 6, (2019)
12345678