Coaxial Electrospun wound dressing integrated with Ag-doped hydroxyapatite for wound healing: Tetracycline delivery

被引:1
作者
Pirzadeh, Kosar [1 ]
Torkian, Leila [2 ,3 ]
Asli, Maryam Daghighi [1 ,2 ]
机构
[1] Islamic Azad Univ, Cent Tehran Branch, Dept Chem, Tehran, Iran
[2] Islamic Azad Univ, South Tehran Branch, Dept Appl Chem, Tehran, Iran
[3] Islamic Azad Univ, South Tehran Branch, Res Ctr Modeling & Optimizat Sci & Engn, Tehran, Iran
来源
MATERIALS TODAY COMMUNICATIONS | 2024年 / 41卷
关键词
Wound dressing; Antibacterial; Hydroxyapatite; Ion doping; Nanotechnology; SILVER; ANTIBACTERIAL; NANOPARTICLES; NANOFIBERS; SCAFFOLD;
D O I
10.1016/j.mtcomm.2024.110439
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
The human body's natural defense against inflammation in wounds can sometimes be insufficient. Introducing a wound dressing with this capability could significantly enhance the healing process. This study aimed to create a PVP/PVA-based coaxial electrospun wound dressing integrated with tetracycline-loaded Ag-doped hydroxyapatite (Ag@iHA) in three concentrations [G1, G2, and G3]) with a focus on drug release and antibacterial activity. Nanoparticles were analyzed using DLS, Zeta potential, SEM, EDX, XRD, and FTIR. The final wound dressing was studied from the viewpoint of physicochemical properties biologically, and finally, it was assessed under an in vivo study (9 Wistar rats, six days). Drug release was measured at three pH (5.4, 7, and 9). The results showed a remarkable success in the integration of silver ion in the hydroxyapatite structure, with a 90-600 nm size. Increasing the content of hydroxyapatite improved the quality of nanofibers that were produced. The nanofibers had high hydrophilicity (<5 & ring;) and swelling rates (70-118 %), which were wholly degraded after 14 days. The amount of the released drug was completely different at each pH and was higher in an alkaline environment, as seen in wounds. The survival percentage (>90 %) of L929 cells showed the biocompatibility of nanofibers. In the animal study, all groups reduced the growth of microorganisms, but the most efficacy belonged to the G3 group. In conclusion, this novel wound dressing has the potential to significantly accelerate the body's natural healing process by controlling the growth of microorganisms.
引用
收藏
页数:13
相关论文
共 53 条
[1]   Electrospun Nanofibers/Nanofibrous Scaffolds Loaded with Silver Nanoparticles as Effective Antibacterial Wound Dressing Materials [J].
Alven, Sibusiso ;
Buyana, Buhle ;
Feketshane, Zizo ;
Aderibigbe, Blessing Atim .
PHARMACEUTICS, 2021, 13 (07)
[2]   Advancements and future directions in the antibacterial wound dressings - A review [J].
Bal-Ozturk, Ayca ;
Ozkahraman, Bengi ;
Ozbas, Zehra ;
Yasayan, Gokcen ;
Tamahkar, Emel ;
Alarcin, Emine .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2021, 109 (05) :703-716
[3]   Silver Nanoparticles and Their Antibacterial Applications [J].
Bruna, Tamara ;
Maldonado-Bravo, Francisca ;
Jara, Paul ;
Caro, Nelson .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (13)
[4]   Antibacterial Activity of Chitosan Nanoparticles: A Review [J].
Chandrasekaran, Murugesan ;
Kim, Ki Deok ;
Chun, Se Chul .
PROCESSES, 2020, 8 (09)
[5]   Biomimetic composite scaffolds based mineralization of hydroxyapatite on electrospun calcium-containing poly(vinyl alcohol) nanofibers [J].
Chang, Wenkai ;
Mu, Xueyan ;
Zhu, Xiaoqun ;
Ma, Guiping ;
Li, Chunguang ;
Xu, Fujian ;
Nie, Jun .
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2013, 33 (07) :4369-4376
[6]   Biomimetic composite scaffold of hydroxyapatite/gelatin-chitosan core-shell nanofibers for bone tissue engineering [J].
Chen, Peng ;
Liu, Leyun ;
Pan, Jiaqi ;
Mei, Jie ;
Li, Chaorong ;
Zheng, Yingying .
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2019, 97 :325-335
[7]   Fe-doped zirconia nanoparticles with highly negative conduction band potential for enhancing visible light photocatalytic performance [J].
Cheng, Qing ;
Yang, Wulin ;
Chen, Qingling ;
Zhu, Jiajun ;
Li, Deyi ;
Fu, Licai ;
Zhou, Lingping .
APPLIED SURFACE SCIENCE, 2020, 530
[8]   Tetracycline antibiotics: Mode of action, applications, molecular biology, and epidemiology of bacterial resistance [J].
Chopra, I ;
Roberts, M .
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2001, 65 (02) :232-+
[9]   Synthesis and Antimicrobial Activity of Silver-Doped Hydroxyapatite Nanoparticles [J].
Ciobanu, Carmen Steluta ;
Iconaru, Simona Liliana ;
Chifiriuc, Mariana Carmen ;
Costescu, Adrian ;
Le Coustumer, Philippe ;
Predoi, Daniela .
BIOMED RESEARCH INTERNATIONAL, 2013, 2013
[10]   Clitorea ternatea-mediated silver nanoparticle-doped hydroxyapatite derived from cockle shell as antibacterial material [J].
Citradewi, Putwi Widya ;
Hidayat, Habibi ;
Purwiandono, Gani ;
Fatimah, Is ;
Sagadevan, Suresh .
CHEMICAL PHYSICS LETTERS, 2021, 769