Carbon dot-based nanomaterials with enzyme-like activity for fluorescence imaging and potential combination with therapy of cancer

被引：0

作者：

Ning, Juan ^{[1
]}

Li, Guojie ^{[2
]}

Zhao, Yijun ^{[1
]}

Shi, Jiahui ^{[1
]}

Nie, Yamin ^{[1
]}

Li, Yonghong ^{[1
]}

Zhou, Yanmei ^{[1
]}

机构：

[1] Henan Univ, Coll Chem & Mol Sci, State Key Lab Antiviral Drugs, Henan Joint Int Res Lab Environm Pollut Control Ma, Kaifeng 475004, Peoples R China

[2] Henan Univ, Huaihe Hosp, Dept Gen Med, Kaifeng 475000, Peoples R China

来源：

MICROCHIMICA ACTA | 2024年 / 191卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Carbon-dot based nanomaterials; Fluorescence imaging; Enzyme-like activity; Photothermal effect;

D O I：

10.1007/s00604-024-06813-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Carbon dot-based nanomaterials (o-CDs@Mn) were fabricated by assembling fluorescent o-CDs with enzyme-like activity and Mn nanoparticles with photothermal properties for realizing fluorescence imaging and combined therapy of cancer. Due to the inherent optical properties of o-CDs, o-CDs@Mn can be effectively used for bioimaging. In addition, o-CDs@Mn possess peroxidase-like (POD-like) and glutathione (GSH) degradation capabilities, which can effectively deplete excessive H2O2 and GSH in the tumor microenvironment (TME), generating <middle dot>OH and reduced GSSH for regulating the TME and triggering ROS-mediated apoptosis in cancer cells. More importantly, it is synergistically supplemented with fluorescence imaging and photothermal therapy (PTT), which realizes the integration of monitoring and combined treatment, providing a promising potential pathway for accurate and efficient cancer treatment.

引用

页数：10