Self-assembled lipid-based nanoparticles for chemotherapy against breast cancer

被引：1

作者：

Liu, Shan ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Songjiang Hosp, Dept Oncol, Sch Med, Shanghai, Peoples R China

来源：

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2024年 / 12卷

基金：

中国国家自然科学基金;

关键词：

self-assembly; lipids; nanoparticles; breast cancer; chemotherapy; LIPOSOME-COMPLEXED MITOXANTRONE; POLYMER HYBRID NANOPARTICLES; DRUG-DELIVERY; PHASE-II; CO-DELIVERY; NANOCARRIERS; PACLITAXEL; PROGRESS; CELLS; DOXORUBICIN;

D O I：

10.3389/fbioe.2024.1482637

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Self-assembled lipid-based nanoparticles have been shown to have improved therapeutic efficacy and lower toxic side effects. Breast cancer is a common type of malignant tumor in women. Conventional drugs such as doxorubicin (DOX) have shown low therapeutic efficacy and high drug toxicity in antitumor therapy. This paper surveys research on self-assembled lipid-based nanoparticles by categorizing them under three groups: self-assembled liposomal nanostructures, self-assembled niosomes, and self-assembled lipid-polymer hybrid nanoparticles. Subsequently, the structural features and operating mechanisms of each group are summarized individually along with examples of representative drugs from each group.

引用

页数：10

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