Recent progress in organelle-targeting fluorescent probes for the detection of peroxynitrite

被引：0

作者：

Li, Lanqing ^{[1
]}

Wang, Chunzheng ^{[1
]}

Hu, Jinhui ^{[1
]}

Chen, Wen-Hua ^{[1
]}

机构：

[1] Wuyi Univ, Sch Pharm & Food Engn, Jiangmen 529020, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 93期

关键词：

PERFORMANCE LIQUID-CHROMATOGRAPHY; ENDOPLASMIC-RETICULUM STRESS; ELECTROCHEMICAL DETECTION; LIVING CELLS; ANTIOXIDANTS; BIOCHEMISTRY; LYSOSOMES; AUTOPHAGY; INTERPLAY; RADICALS;

D O I：

10.1039/d4cc03452j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Peroxynitrite (ONOO-), as an important reactive nitrogen species, plays a pivotal role in the regulation of intracellular redox homeostasis, signal transduction, cell growth and metabolism, and other physiological processes. Organelles are important for regulating ONOO-, and the dysregulation of ONOO- in organelles is closely related to various diseases. Therefore, it is essential to monitor ONOO- in cellular organelles, including mitochondria, lysosome, endoplasmic reticulum (ER), Golgi apparatus, and lipid droplets. However, the latest advances in organelle-targeting ONOO- fluorescent probes have not been reviewed systematically. In this review, we focus on the design, sensing mechanism, and organelle-targeting imaging applications of ONOO- fluorescent probes that were reported since 2018. This review will help to facilitate the comprehension of organelle-targeting fluorescent probes for the detection of ONOO-.

引用

页码：13629 / 13640

页数：12

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