Photoredox catalyzed reductive trifluoromethylation of imines via a radical umpolung strategy

被引：0

作者：

Paul, Hrishikesh ^{[1
]}

Das, Dibyangshu ^{[1
]}

Ariyan, S. K. ^{[1
]}

Pradhan, Suman ^{[1
]}

Chatterjee, Indranil ^{[1
]}

机构：

[1] Indian Inst Technol Ropar, Dept Chem, Nangal Rd, Rupnagar 140001, Punjab, India

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 89期

关键词：

ALPHA-AMINO RADICALS; ELECTRON-TRANSFER; ALKYLATION; ACID; DERIVATIVES; ALDEHYDES;

D O I：

10.1039/d4cc03897e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Visible light-induced radical umpolung chemistry is utilized to synthesize trifluoromethylated unnatural alpha-amino acid and amine derivatives. This approach utilizes photoredox catalysis to perform a single-electron-transfer reduction of imines generating a N-centred radical that eventually migrates to the C-centre followed by a radical-radical cross-coupling to deliver reductive trifluoromethylation products.

引用

页码：13016 / 13019

页数：4

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