Access to tetrahydrocarbazoles via a photocatalyzed cascade decarboxylation/addition/cyclization reaction

被引：1

作者：

Han, Shuai ^{[1
]}

Chen, Zhang ^{[1
]}

Guo, Yu ^{[1
]}

Chen, Jinjin ^{[1
]}

Wang, Zhen ^{[1
,2
,3
]}

Zeng, Yao-Fu ^{[1
]}

机构：

[1] Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China

[2] Univ South China, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China

[3] Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2024年 / 11卷 / 23期

基金：

中国国家自然科学基金;

关键词：

DIELS-ALDER REACTIONS; REDOX-ACTIVE ESTERS; FUNCTIONALIZED TETRAHYDROCARBAZOLES; ASYMMETRIC-SYNTHESIS; ALLYLIC ALKYLATION; EFFICIENT ROUTE; CATALYSIS; COMPLEX; CONSTRUCTION; INDOLES;

D O I：

10.1039/d4qo01357c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient photocatalyzed decarboxylative coupling of indolepropionic acid NHPI esters with alpha,beta-unsaturated carbonyl compounds has been developed. Various alpha,beta-unsaturated carbonyl compounds including esters, ketones, aldehydes, and amides showed good compatibility, providing structurally diverse tetrahydrocarbazoles in moderate to good yields. This approach features a wide substrate scope and mild reaction conditions. The synthetic value of this method was further demonstrated by the post-transformation of the product into carbazole.

引用

页码：6694 / 6699

页数：6

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