Access to tetrahydrocarbazoles via a photocatalyzed cascade decarboxylation/addition/cyclization reaction

被引：1
|
作者：
Han, Shuai [1 ]
Chen, Zhang [1 ]
Guo, Yu [1 ]
Chen, Jinjin [1 ]
Wang, Zhen [1 ,2 ,3 ]
Zeng, Yao-Fu [1 ]
机构：
[1] Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China
[2] Univ South China, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China
[3] Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2024年 / 11卷 / 23期
基金：
中国国家自然科学基金;
关键词：
DIELS-ALDER REACTIONS; REDOX-ACTIVE ESTERS; FUNCTIONALIZED TETRAHYDROCARBAZOLES; ASYMMETRIC-SYNTHESIS; ALLYLIC ALKYLATION; EFFICIENT ROUTE; CATALYSIS; COMPLEX; CONSTRUCTION; INDOLES;
D O I：
10.1039/d4qo01357c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient photocatalyzed decarboxylative coupling of indolepropionic acid NHPI esters with alpha,beta-unsaturated carbonyl compounds has been developed. Various alpha,beta-unsaturated carbonyl compounds including esters, ketones, aldehydes, and amides showed good compatibility, providing structurally diverse tetrahydrocarbazoles in moderate to good yields. This approach features a wide substrate scope and mild reaction conditions. The synthetic value of this method was further demonstrated by the post-transformation of the product into carbazole.
引用
收藏
页码：6694 / 6699
页数：6
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