Gene-environment interactions in the influence of maternal education on adolescent neurodevelopment using ABCD study

被引：1

作者：

Shi, Runye ^{[1
]}

Chang, Xiao ^{[2
,3
,4
,5
]}

Banaschewski, Tobias ^{[6
]}

Barker, Gareth J. ^{[7
]}

Bokde, Arun L. W. ^{[8
]}

Desrivieres, Sylvane ^{[9
]}

Flor, Herta ^{[10
,11
]}

Grigis, Antoine ^{[12
]}

Garavan, Hugh ^{[13
]}

Gowland, Penny ^{[14
]}

Heinz, Andreas ^{[15
]}

Bruehl, Ruediger ^{[16
]}

Martinot, Jean-Luc ^{[17
]}

Martinot, Marie-Laure Paillere ^{[18
]}

Artiges, Eric ^{[17
,19
]}

Nees, Frauke ^{[6
,10
,20
]}

Orfanos, Dimitri Papadopoulos ^{[12
]}

Poustka, Luise ^{[21
]}

Hohmann, Sarah ^{[6
,22
]}

Holz, Nathalie ^{[6
]}

Smolka, Michael N. ^{[23
]}

Vaidya, Nilakshi ^{[24
]}

Walter, Henrik ^{[15
]}

Whelan, Robert ^{[25
]}

Schumann, Gunter ^{[24
,26
]}

Lin, Xiaolei ^{[1
]}

Feng, Jianfeng ^{[1
,2
,3
,4
,5
,27
]}

机构：

[1] Fudan Univ, Sch Data Sci, Shanghai, Peoples R China

[2] Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China

[3] Fudan Univ, Key Lab Computat Neurosci & Brain Inspired Intelli, Minist Educ, Shanghai, Peoples R China

[4] Fudan Univ, MOE Frontiers Ctr Brain Sci, Shanghai, Peoples R China

[5] Zhangjiang Fudan Int Innovat Ctr, Shanghai, Peoples R China

[6] Heidelberg Univ, Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, Med Fac Mannheim, Sq J5, D-68159 Mannheim, Germany

[7] Kings Coll London, Dept Neuroimaging, Inst Psychiat Psychol & Neurosci, London, England

[8] Trinity Coll Dublin, Sch Med, Trinity Coll Inst Neurosci, Discipline Psychiat, Dublin, Ireland

[9] Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England

[10] Heidelberg Univ, Med Fac Mannheim, Inst Cognit & Clin Neurosci, Cent Inst Mental Hlth, Sq J5, Mannheim, Germany

[11] Univ Mannheim, Sch Social Sci, Dept Psychol, D-68131 Mannheim, Germany

[12] Univ Paris Saclay, CEA, CNRS, Gif Sur Yvette, France

[13] Univ Vermont, Dept Psychiat & Psychol, Burlington, VT 05405 USA

[14] Univ Nottingham, Sir Peter Mansfield Imaging Ctr, Sch Phys & Astron, Univ Pk, Nottingham, England

[15] Free Univ Berlin, Inst Radiol, Humboldt Univ Berlin, Charite Univ Med Berlin, Berlin, Germany

[16] Phys Tech Bundesanstalt PTB, Braunschweig, Germany

[17] Univ Paris Saclay, Ecole Normale Super Paris Saclay, Ctr Borelli, Gif Sur Yvette, France

[18] Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Dept Child & Adolescent Psychiat, Paris, France

[19] EPS Barthelemy Durand, Psychiat Dept, Etampes, France

[20] Univ Kiel, Univ Med Ctr Schleswig Holstein, Inst Med Psychol & Med Sociol, Kiel, Germany

[21] Univ Med Ctr Gottingen, Dept Child & Adolescent Psychiat & Psychotherapy, von Siebold Str 5, D-37075 Gottingen, Germany

[22] Univ Med Ctr Hamburg Eppendorf, Dept Child & Adolescent Psychiat Psychotherapy, Hamburg, Germany

[23] Tech Univ Dresden, Dept Psychiat & Psychotherapy, Dresden, Germany

[24] Charite Univ Med Berlin, Ctr Populat Neurosci & Stratified Med PONS, Dept Psychiat & Psychotherapy, Berlin, Germany

[25] Trinity Coll Dublin, Global Brain Hlth Inst, Inst Neurosci, Dublin, Ireland

[26] Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence IST, Ctr Populat Neurosci & Precis Med PONS, Shanghai, Peoples R China

[27] Univ Warwick, Dept Comp Sci, Coventry, England

来源：

SCIENCE ADVANCES | 2024年 / 10卷 / 46期

基金：

中国国家自然科学基金; 英国医学研究理事会; 国家重点研发计划; 爱尔兰科学基金会; 英国科研创新办公室; 欧盟地平线“2020”; 美国国家卫生研究院;

关键词：

GENOME-WIDE ASSOCIATION; SOCIOECONOMIC-STATUS; PARENTAL EDUCATION; BRAIN STRUCTURE; CHILD-DEVELOPMENT; SOCIAL-CLASS; C/EBP-ALPHA; BEHAVIOR; CELLS; LOCI;

D O I：

10.1126/sciadv.adp3751

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Maternal education was strongly correlated with adolescent brain morphology, cognitive performances, and mental health. However, the molecular basis for the effects of maternal education on the structural neurodevelopment remains unknown. Here, we conducted gene-environment-wide interaction study using the Adolescent Brain Cognitive Development cohort. Seven genomic loci with significant gene-environment interactions (GxE) on regional gray matter volumes were identified, with enriched biological functions related to metabolic process, inflammatory process, and synaptic plasticity. Additionally, genetic overlapping results with behavioral and disease-related phenotypes indicated shared biological mechanism between maternal education modified neurodevelopment and related behavioral traits. Finally, by decomposing the multidimensional components of maternal education, we found that socioeconomic status, rather than family environment, played a more important role in modifying the genetic effects on neurodevelopment. In summary, our study provided analytical evidence for GxE effects regarding adolescent neurodevelopment and explored potential biological mechanisms as well as social mechanisms through which maternal education could modify the genetic effects on regional brain development.

引用

页数：18

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