Antimicrobial GL13K Peptide-Decorated ZnO Nanoparticles To Treat Bacterial Infections

被引：0

作者：

Zhang, Xu ^{[1
,2
,3
]}

Liu, Yinghao ^{[1
,3
]}

Zhang, Xue'e ^{[1
,2
,3
]}

Tang, Mengzhen ^{[1
,2
,3
]}

Xi, Weihong ^{[1
,2
,3
]}

Wei, Junchao ^{[1
,2
,3
,4
]}

机构：

[1] Nanchang Univ, Jiangxi Med Coll, Sch Stomatol, Nanchang 330006, Jiangxi, Peoples R China

[2] Jiangxi Prov Key Lab Oral Dis, Nanchang 330006, Jiangxi, Peoples R China

[3] Jiangxi Prov Clin Res Ctr Oral Dis, Nanchang 330006, Jiangxi, Peoples R China

[4] Nanchang Univ, Sch Chem & Chem Engn, Nanchang 330031, Jiangxi, Peoples R China

来源：

LANGMUIR | 2024年 / 40卷 / 47期

基金：

中国国家自然科学基金;

关键词：

30;

D O I：

10.1021/acs.langmuir.4c03206

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

As a broad-spectrum antimicrobial material, ZnO nanoparticles (NPs) offer a novel approach to infected wounds in the clinic; however, it is very necessary to improve the antimicrobial performance of ZnO to satisfy the clinic requirements. In this work, a new antimicrobial hybrid ZnO@PDA/GL13K was prepared by attaching the antimicrobial GL13K peptide on the surface of ZnO NPs via polydopamine (PDA) as a covalent bonding agent, which can enhance the reactive oxygen species (ROS) production and damage the cell wall, showing superior antimicrobial efficacy. Besides, the ZnO@PDA/GL13K hybrid can promote the healing of bacterial infected wounds, with the wound area only remaining 1.8% on day 9, about 2 times smaller than that of the ZnO group. Moreover, ZnO@PDA/GL13K also showed good biocompatibility, and no side effect on normal tissue and organs was found, implying that the antimicrobial hybrid may possess prospective application in biomedical fields.

引用

页码：25042 / 25050

页数：9