Antimicrobial GL13K Peptide-Decorated ZnO Nanoparticles To Treat Bacterial Infections

被引:0
|
作者
Zhang, Xu [1 ,2 ,3 ]
Liu, Yinghao [1 ,3 ]
Zhang, Xue'e [1 ,2 ,3 ]
Tang, Mengzhen [1 ,2 ,3 ]
Xi, Weihong [1 ,2 ,3 ]
Wei, Junchao [1 ,2 ,3 ,4 ]
机构
[1] Nanchang Univ, Jiangxi Med Coll, Sch Stomatol, Nanchang 330006, Jiangxi, Peoples R China
[2] Jiangxi Prov Key Lab Oral Dis, Nanchang 330006, Jiangxi, Peoples R China
[3] Jiangxi Prov Clin Res Ctr Oral Dis, Nanchang 330006, Jiangxi, Peoples R China
[4] Nanchang Univ, Sch Chem & Chem Engn, Nanchang 330031, Jiangxi, Peoples R China
基金
中国国家自然科学基金;
关键词
30;
D O I
10.1021/acs.langmuir.4c03206
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
As a broad-spectrum antimicrobial material, ZnO nanoparticles (NPs) offer a novel approach to infected wounds in the clinic; however, it is very necessary to improve the antimicrobial performance of ZnO to satisfy the clinic requirements. In this work, a new antimicrobial hybrid ZnO@PDA/GL13K was prepared by attaching the antimicrobial GL13K peptide on the surface of ZnO NPs via polydopamine (PDA) as a covalent bonding agent, which can enhance the reactive oxygen species (ROS) production and damage the cell wall, showing superior antimicrobial efficacy. Besides, the ZnO@PDA/GL13K hybrid can promote the healing of bacterial infected wounds, with the wound area only remaining 1.8% on day 9, about 2 times smaller than that of the ZnO group. Moreover, ZnO@PDA/GL13K also showed good biocompatibility, and no side effect on normal tissue and organs was found, implying that the antimicrobial hybrid may possess prospective application in biomedical fields.
引用
收藏
页码:25042 / 25050
页数:9
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