A Ru(<sc>ii</sc>) complex-based COX-2 targeting type I photosensitizer evokes ferroptosis and apoptosis

被引：2
|
作者：
Qi, Fen [1 ,3 ]
Zheng, Xiaoxue [1 ]
Wu, Yanping [1 ]
Li, Shumeng [1 ]
Yao, Shankun [1 ]
He, Weijiang [1 ]
Chen, Yuncong [1 ,2 ]
Guo, Zijian [1 ]
机构：
[1] Nanjing Univ, Chem & Biomed Innovat Ctr ChemBIC, ChemBioMed Interdisciplinary Res Ctr, Sch Chem & Chem Engn,State Key Lab Coordinat Chem, Nanjing 210023, Jiangsu, Peoples R China
[2] Nanjing Univ, Nanjing Drum Tower Hosp, Med Sch, Dept Cardiothorac Surg, Nanjing 210008, Jiangsu, Peoples R China
[3] Wuxi Inst Technol, Kai Yuan Sch Innovat & Entrepreneurship, Wuxi 214121, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 89期
基金：
中国国家自然科学基金;
关键词：
MECHANISMS; BREAST;
D O I：
10.1039/d4cc04217d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Photodynamic therapy (PDT) often faces challenges such as oxygen dependence and limited tumour specificity. We report a tumour-targeting photosensitizer (PS), RuCXB, which enhances uptake by cancer cells by targeting overexpressed cyclooxygenase-2 enzyme in tumours. RuCXB also reduces oxygen dependence via a type I PDT mechanism and achieves a strong therapeutic effect through the synergistic induction of ferroptosis and apoptosis. This work presents a reliable strategy for developing potent PSs with enhanced PDT efficacy, tumour selectivity, and diminished oxygen dependence.
引用
收藏
页码：13091 / 13094
页数：4
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