Trial-by-Trial Variability of TMS-EEG in Healthy Controls and Patients With Depressive Disorder

被引:0
|
作者
Niu, Zikang [1 ,2 ]
Jia, Lina [3 ,4 ]
Li, Yang [4 ]
Yang, Lijuan [4 ]
Liu, Yi [4 ]
Lian, Siyuan [4 ]
Wang, Dan [4 ]
Wang, Wen [4 ]
Yang, Liu [1 ]
Pan, Weigang [4 ]
Li, Xiaoli [5 ,6 ]
机构
[1] Air Force Med Ctr, Aviat Psychol Res Off, Beijing 100142, Peoples R China
[2] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
[3] Capital Med Univ, Xuanwu Hosp, Beijing 100053, Peoples R China
[4] Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing 100088, Peoples R China
[5] Guangdong Artificial Intelligence & Digital Econ, Guangzhou 510335, Peoples R China
[6] South China Univ Technol, Sch Automat Sci & Engn, Guangzhou 510641, Peoples R China
关键词
TMS-EEG; trial-by-trial variability; depressive disorder; TRANSCRANIAL MAGNETIC STIMULATION; SIGNAL VARIABILITY; BIPOLAR DISORDER; CONNECTIVITY; RESPONSES; DYNAMICS; MARKERS; COIL;
D O I
10.1109/TNSRE.2024.3486759
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Depressive disorder has been known to be associated with high variability in resting-state electroencephalography (EEG) signals. However, this phenomenon is often ignored in stimulus-related brain activities. This study proposed a new method to explore the EEG variability evoked by transcranial magnetic stimulation (TMS, TMS-EEG) in depressive disorder (DE) patients. The TMS-EEG data were collected from 34 DE patients and 36 healthy controls (HC). The maximum eigenvalue of the real binary correlation matrix, calculated between different trials using cross-correlation and surrogate methods, was extracted to assess trial-by-trial variability (TTV) of TMS-EEG. The new method was found to more sensitive and reliable than the standard deviation method. DE patients exhibited significantly smaller TTV in Gamma band and greater TTV in Delta band than HC. Furthermore, the HAMD-17 scores were negatively correlated with TTV values in Gamma band. This study represented the first investigation into the TTV in TMS-EEG data and revealed abnormal values in DE patients. Those findings enhance our understanding of TMS-EEG technology and provide valuable insights for studying the characteristics of DE.
引用
收藏
页码:3869 / 3877
页数:9
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