Deciphering the Wound-Healing Potential of Collagen Peptides and the Molecular Mechanisms: A Review

被引:1
|
作者
Li, Yunying [1 ,2 ]
Lu, Yujia [3 ]
Zhao, Yuchen [3 ]
Zhang, Na [4 ]
Zhang, Yuhao [1 ,5 ]
Fu, Yu [1 ,5 ]
机构
[1] Southwest Univ, Coll Food Sci, Chongqing 400715, Peoples R China
[2] Southwest Univ, Westa Coll, Chongqing 400715, Peoples R China
[3] Harvard Univ, TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[4] Harbin Univ Commerce, Coll Food Engn, Key Lab Food Sci & Engn Heilongjiang Prov, Harbin 150076, Peoples R China
[5] Chongqing Key Lab Special Food Cobuilt Sichuan & C, Chongqing 400715, Peoples R China
基金
中国国家自然科学基金;
关键词
collagen peptides; imino acids; wound-healingmodel; fibroblasts; molecular mechanism; CELL-PROLIFERATION; CRYPTIC PEPTIDES; SKIN; CHITOSAN; TILAPIA; EXPRESSION;
D O I
10.1021/acs.jafc.4c02960
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
Collagen peptides have been reported to display various bioactivities and high bioavailability. Recently, increasing evidence has revealed the excellent wound-healing activity of collagen peptides, but their molecular mechanisms remain incompletely elucidated. This review systematically evaluates the therapeutic efficacy of collagen peptides from diverse sources based on various wound models. Furthermore, the structure-activity relationships of collagen peptides and wound-healing mechanisms are discussed and summarized. Characterized by their low molecular weight and abundant imino acids, collagen peptides facilitate efficient absorption by the body to deliver nutrition throughout the wound-healing process. The specific mechanism of collagen peptide for wound healing is mainly through up-regulation of related cytokines and participation in the activation of relevant signaling pathways, such as TGF-beta/Smad and PI3K/Akt/mTOR, which can promote cell proliferation, angiogenesis, collagen synthesis and deposition, re-epithelialization, and ECM remodeling, ultimately achieving the effect of wound healing. Collagen peptides can offer a potential therapeutic approach for treating incision and excision wounds, mucosal injuries, burn wounds, and pressure ulcers, improving the efficiency of wound healing by about 10%-30%. The present review contributes to understanding of the wound-healing potential of collagen peptides and the underlying molecular mechanisms.
引用
收藏
页码:26007 / 26026
页数:20
相关论文
共 50 条
  • [21] Collagen sponge “cytothymacol”: A wound-healing stimulator
    V. V. Malinin
    M. A. Burakova
    N. D. Sidorova
    R. K. Aboyants
    L. P. Istranov
    E. V. Istranova
    T. G. Rudenko
    L. S. Efimova
    Pharmaceutical Chemistry Journal, 1998, 32 (11) : 622 - 624
  • [22] WOUND-HEALING POTENTIAL OF CULTURED EPITHELIUM
    COMPTON, CC
    WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE, 1993, 5 (02): : 97 - 111
  • [23] A brief update on potential molecular mechanisms underlying antimicrobial and wound-healing potency of snake venom molecules
    Samy, Ramar Perumal
    Sethi, Gautam
    Lim, Lina H. K.
    BIOCHEMICAL PHARMACOLOGY, 2016, 115 : 1 - 9
  • [24] PENICILLAMINE AND WOUND-HEALING - POTENTIAL HAZARD
    BURRY, HC
    POSTGRADUATE MEDICAL JOURNAL, 1974, 50 : 75 - 76
  • [25] Wound-Healing Molecular Trigger Found
    不详
    GENETIC ENGINEERING & BIOTECHNOLOGY NEWS, 2012, 32 (15): : 62 - 62
  • [26] Honey-Propolis-Engineered Collagen Peptides as Promising Wound-Healing Matrix in Mouse Model
    Ibrahim, Hairul-Islam Mohamed
    Thangavelu, Muthukumar
    Khalifa, Ashraf
    MOLECULES, 2022, 27 (20):
  • [27] WOUND-HEALING FOR THE DERMATOLOGIC SURGEON - REVIEW
    GOSLEN, JB
    JOURNAL OF DERMATOLOGIC SURGERY AND ONCOLOGY, 1988, 14 (09): : 959 - 972
  • [28] FIBRONECTIN IN CORNEAL WOUND-HEALING - REVIEW
    DING, M
    BURSTEIN, NL
    JOURNAL OF OCULAR PHARMACOLOGY, 1988, 4 (01): : 75 - 91
  • [29] THE BIOLOGY OF FETAL WOUND-HEALING - A REVIEW
    LONGAKER, MT
    ADZICK, NS
    PLASTIC AND RECONSTRUCTIVE SURGERY, 1991, 87 (04) : 788 - 798
  • [30] ELECTROSURGERY AND WOUND-HEALING - A REVIEW OF THE LITERATURE
    WILLIAMS, VD
    JOURNAL OF THE AMERICAN DENTAL ASSOCIATION, 1984, 108 (02): : 220 - 222