An activatable red emitting fluorescent probe for monitoring vicinal dithiol protein fluctuations in a stroke model

被引：0

作者：

Shen, Ruipeng ^{[1
,2
]}

Chen, Ya-xiong ^{[1
,2
]}

Chen, Yating ^{[1
,2
]}

Sayed, Zahid Nasim ^{[1
,2
]}

Yi, Meirong ^{[1
,2
]}

Sun, Chunlin ^{[1
,2
]}

Zhang, Baoxin ^{[1
,2
]}

Fang, Jianguo ^{[1
,2
,3
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

[2] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China

[3] Nanjing Univ Sci & Technol, Sch Chem & Chem Engn, Nanjing 210094, Jiangsu, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 93期

基金：

中国国家自然科学基金;

关键词：

CEREBRAL-ISCHEMIA; FLUOROGENS; DEATH;

D O I：

10.1039/d4cc04971c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Vicinal dithiol proteins (VDPs) facilitate cellular redox homeostasis, modulate protein synthesis and participate in post-translational modifications through the dynamic equilibrium of dithiol and disulfide bonds. Herein, an activatable red emitting fluorescent probe, VDP-red, is developed for detecting VDPs. With the aid of this probe, we have discovered for the first time a reduction in the levels of reduced VDPs in a stroke mouse model. This work provides a fresh viewpoint for understanding stroke mechanisms.

引用

页码：13774 / 13777

页数：4

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