FAP-Targeted Nanoparticle-based Imaging in Cancer: A Systematic Review

被引：4

作者：

Abbasi, Samaneh ^{[1
]}

Khademi, Sara ^{[2
]}

Montazerabadi, Alireza ^{[1
,3
]}

Sahebkar, Amirhossein ^{[4
,5
,6
]}

机构：

[1] Department of Medical Physics, School of Medicine, Mashhad University of Medical Sciences, Mashhad

[2] Department of Radiology Technology, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad

[3] Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad

[4] Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai

[5] Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad

[6] Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad

来源：

Journal of Biomedical Physics and Engineering | 2024年 / 14卷 / 04期

关键词：

Fibroblast Activation Protein (FAP); Imaging; Molecular Imaging; Nanoparticles (NPs); Neoplasms;

D O I：

10.31661/jbpe.v0i0.2404-1754

中图分类号：

学科分类号：

摘要：

Background: Fibroblast Activation Protein (FAP)-targeted nanoparticles (NPs) are designed to accumulate in cancerous stroma. These NPs hold promise for imaging applications in cancer therapy. Objective: This systematic review aimed to comprehensively explore the use of FAP-targeting NPs for cancer diagnosis through different imaging modalities. Material and Methods: This systematic review followed the framework pro-posed by O’Malley and Arksey. Peer-reviewed studies were searched in the Scopus, Science Direct, PubMed, and Google Scholar databases. Eligible studies were selected, and data were extracted to investigate the FAP-targeting NPs in imaging. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was also utilized to present the results. Results: Five studies met the specified inclusion criteria and were finally selected for analysis. The extracted data was classified into two categories: general and specific data. The general group indicated that most studies have been conducted in Mexico and have increased since 2022, and the specific group showed that colorectal cancer and Nude mice have received the most research attention. Furthermore, FAP-targeted NPs have demonstrated superior diagnostic imaging capabilities, even compared to specific methods for each cancer type. Also, they have been safe, with no toxicity. Conclusion: FAP-targeted NPs using different ligands, such as Fibroblast Activation Protein Inhibitor (FAPI), can accurately detect tumors and metastases, and outper-form specific cancer peptides like PSMA in cancer diagnosis. They are also non-toxic and do not cause radiation damage to tissues. Therefore, FAP-targeted NPs have the potential to serve as a viable alternative to FAP-targeted radionuclides for cancer diagnosis. © Journal of Biomedical Physics and Engineering.

引用

页码：323 / 334

页数：11

共 57 条

[1]

Valkenburg KC, de Groot AE, Pienta KJ., Targeting the tumour stroma to improve cancer therapy, Nat Rev Clin Oncol, 15, 6, pp. 366-381, (2018)

[2]

Kalluri R., The biology and function of fibroblasts in cancer, Nat Rev Cancer, 16, 9, pp. 582-598, (2016)

[3]

Micallef L, Vedrenne N, Billet F, Coulomb B, Darby IA, Desmouliere A., The myofibroblast, multiple origins for major roles in normal and patho-logical tissue repair, Fibrogenesis Tissue Repair, 5, (2012)

[4]

Messerschmidt SK, Musyanovych A, Altvater M, Scheurich P, Pfizenmaier K, Landfester K, Kon-termann RE., Targeted lipid-coated nanoparticles: delivery of tumor necrosis factor-functional-ized particles to tumor cells, J Control Re-lease, 137, 1, pp. 69-77, (2009)

[5]

Ma J, Dai L, Yu J, Cao H, Bao Y, Hu J, Et al., Tumor microenvironment targeting system for glioma treatment via fusion cell membrane coating nanotechnology, Biomaterials, 295, (2023)

[6]

Zhang L, Ying W, Sheng Z, Lv L, Gao J, Xue Y, Liu L., Bioluminescence imaging of fibroblast activation pro-tein-alpha in vivo and human plas-ma with highly sensitive probe, Anal Biochem, 655, (2022)

[7]

Zhou S, Zhen Z, Paschall AV, Xue L, Yang X, Bebin-Blackwell AG, Et al., FAP-Targeted Photody-namic Therapy Mediated by Ferritin Nanoparticles Elicits an Immune Response against Cancer Cells and Cancer As-sociated Fibroblasts, Adv Funct Mater, 31, 7, (2021)

[8]

Borgonje PE, Andrews LM, Herder GJM, de Klerk JMH., Performance and Prospects of [68Ga] Ga-FAPI PET/CT Scans in Lung Cancer, Can-cers (Basel), 14, 22, (2022)

[9]

Sollini M, Kirienko M, Gelardi F, Fiz F, Gozzi N, Chiti A., State-of-the-art of FAPI-PET imaging: a systematic review and meta-analysis, Eur J Nucl Med Mol Imaging, 48, 13, pp. 4396-4414, (2021)

[10]

Zhu H, Yang C, Yan A, Qiang W, Ruan R, Ma K, Et al., Tumor‐targeted nano‐adjuvants to syner-gize photo-mediated immunotherapy enhanced antitumor immunity, View, (2023)

← 1 2 3 4 5 6 →