Associations between metal(loid) exposure with overweight and obesity and abdominal obesity in the general population: A cross-sectional study in China

被引：5
作者：
Shen T. [1 ,2 ]
Zhong L. [1 ,2 ]
Ji G. [3 ]
Chen B. [1 ,2 ]
Liao M. [1 ,2 ]
Li L. [1 ,2 ]
Huang H. [1 ,2 ]
Li J. [1 ,2 ]
Wei Y. [1 ,2 ]
Wu S. [1 ,2 ]
Chen Z. [3 ]
Ma W. [4 ,5 ]
Dong M. [6 ]
Wu B. [6 ]
Liu T. [4 ,5 ]
Chen Q. [1 ,2 ,7 ]
机构：
[1] Guangdong Pharmaceutical University, Guangzhou
[2] Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, School of Public Health, Guangdong Pharmaceutical University, Guangzhou
[3] Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou
[4] Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou
[5] China Greater Bay Area Research Center of Environmental Health, School of Medicine, Jinan University, Guangzhou
[6] Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou
[7] NMPA Key Laboratory for Technology Research and Evaluation of Pharmacovigilance, Guangdong Pharmaceutical University, Guangzhou
来源：
Chemosphere | 2024年 / 350卷
关键词：
Abdominal obesity; Cross-sectional study; General population; Overweight and obese; Quantile g-computation; Whole blood metal(loid);
D O I：
10.1016/j.chemosphere.2023.140963
中图分类号：
学科分类号：
摘要：
Previous studies have revealed links between metal(loid)s and health problems; however, the link between metal(loid)s and obesity remains controversial. We evaluated the cross-sectional association between metal(loid) exposure in whole blood and obesity among the general population. Vanadium (V), chromium (Cr), manganese (Mn), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), arsenic (As), selenium (Se), molybdenum (Mo), cadmium (Cd), antimony (Sb), thallium (T1), and lead (Pb) were measured in 3029 subjects in Guangdong Province (China) using ICP-MS. The prevalence of overweight and obesity (OWO) and abdominal obesity (AOB) was calculated according to body mass index (BMI) and waist circumference (WC), respectively. Multivariate analysis showed that elevated blood Cu, Cd, and Pb levels were inversely associated with the risk of OWO, and these associations were confirmed by a linear dose-response relationship. Elevated blood Co concentration was associated with a decreased risk of AOB. A quantile g-computation approach showed a significantly negative mixture-effect of 13 metal(loid)s on OWO (OR: 0.96; 95% CI: 0.92, 0.99). Two metals—Ni and Mo—were inversely associated with the risk of OWO but positively associated with AOB. We cross-grouped the two obesity measurement types and found that the extremes of metal content were present in people with AOB only. In conclusion, blood Cu, Mo, Ni, Cd, and Pb were inversely associated with the risk of OWO. The presence of blood Co may be protective, while Ni and Mo exposure might increase the risk of AOB. The association between metal(loid) exposure and obesity warrants further investigation in longitudinal cohort studies. © 2023 The Authors
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