Effects of Sacha Inchi Leaf Alcohol Eхtract on Delaying Aging of Caenorhabditis elegans

被引：0

作者：

Lai Y. ^{[1
]}

Chen Y. ^{[1
]}

Wei W. ^{[1
]}

An M. ^{[1
]}

Zou Z. ^{[1
]}

Du B. ^{[1
]}

Li P. ^{[1
]}

机构：

[1] College of Food Science, South China Agricultural University, Guangzhou

来源：

Science and Technology of Food Industry | 2023年 / 44卷 / 21期

关键词：

alcohol extract; Caenorhabditis elegans; oxidative aging; Sacha inchi leaf;

D O I：

10.13386/j.issn1002-0306.2023020176

中图分类号：

学科分类号：

摘要：

In this study, the effects of different mass concentrations (5, 10 and 15 mg/mL) of Sacha inchi leaf alcohol extract (SILAE) on Caenorhabditis elegans (C. elegans) longevity, mobility, reproductive capacity, resistance to oxidative stress and levels of ROS, lipofuscin and malondialdehyde (MDA) in vivo, as well as the effects of SILAE on enzymatic and non-enzymatic antioxidants in C. elegans were investigated by constructing a senescence model of C. elegans, with the aim of providing certain theoretical references to the further research and application of Sacha inchi leaf. The results showed that SILAE at 5 and 10 mg/mL significantly prolonged the life span of C. elegans compared with the blank group (P<0.05) by 59.3% and 30.2%, respectively, and 15 mg/mL SILAE also prolonged their life span but without significant differences. Meanwhile, their reproductive and motility abilities were also effectively improved by SILAE. In oxidative stress environments, SILAE prolonged the life span of C. elegans under H2O2 stress by approximately 2, 4, and 5-fold, respectively, and 5 and 10 mg/mL of SILAE also significantly prolonged the life span of C. elegans under juglone stress (P<0.05). The accumulation of ROS, lipofuscin (P<0.001), and MDA (P<0.05) in C. elegans was reduced to varying degrees by SILAE. In addition, both superoxide dismutase and catalase activities in C. elegans were highly significantly increased by SILAE (P<0.001), while glutathione peroxidase activity and glutathione content were significantly increased by SILAE at 5 mg/mL (P<0.05) and 10 mg/mL (P<0.01), respectively. In conclusion, SILAE has anti-aging property and is a new possible source of functional foods or alternative drugs with oxidative mitigation and aging retardation effects. © 2023 The Author(s).

引用

页码：402 / 411

页数：9

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