未找到相关数据
11-Step Total Synthesis of Araiosamines
被引：0
|作者：
机构：
[1] Tian, Maoqun
[2] Yan, Ming
[3] Baran, Phil S.
来源：
Baran, Phil S. (pbaran@scripps.edu)
|
1600年
/
American Chemical Society卷
/
138期
关键词：
A concise route to a small family of exotic marine alkaloids known as the araiosamines has been developed;
and their absolute configuration has been assigned. The dense array of functionality;
high polarity;
and rich stereochemistry coupled with equilibrating topologies present an unusual challenge for chemical synthesis and an opportunity for innovation. Key steps involve the use of a new reagent for guanidine installation;
a remarkably selective C-H functionalization;
and a surprisingly simple final step that intersects a presumed biosynthetic intermediate. Synthetic araiosamines were shown to exhibit potency against Gram-positive and -negative bacteria despite a contrary report of no activity. © 2016 American Chemical Society;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Journal article (JA)
引用
收藏
相关论文