Low temperature calorimetry of 3-fluoro-5-(3-pyridinyloxy) Benzenamine and N-[3-fluoro-5-(3-pyridinyloxy)phenyl]-N’-3-pyridinyl urea

被引：1

作者：

Li, Rongchun ^{[1
]}

Sun, Keyan ^{[2
]}

Hua, Yushan ^{[1
]}

Tan, Zhicheng ^{[2
]}

Shi, Quan ^{[2
]}

机构：

[1] Key Laboratory of Coordination Chemistry and Functional Materials, College of Chemistry and Chemical Engineering, Dezhou University, Dezhou, Shandong,253023, China

[2] Thermochemistry Laboratory, Liaoning Province Key Laboratory of Thermochemistry for Energy and Materials, Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian,116023, China

来源：

International Journal of Thermodynamics | 2017年 / 20卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Curve fitting - Metabolism - Calorimetry - Temperature - Calorimeters - Specific heat;

D O I：

10.5541/eoguijt.292047

中图分类号：

学科分类号：

摘要：

The investigation on thermodynamic properties of drug intermediates plays a crucial role in the design and synthesis of new drugs as well as understanding their biological activities in vivo. In this work, the thermodynamic properties of two drug intermediates of 3-fluoro-5-(3-pyridinyloxy) benzenamine and N-[3-fluoro-5-(3-pyridinyloxy)phenyl]-N’-3-pyridinyl urea were studied by means of low temperature calorimety performed in a Physical Property Measurement System calorimeter. The heat capacities of these two compounds were measured over the temperature region from (1.9 to 300) K, and the corresponding thermodynamic functions were consequently calculated on the basis of the heat capacity curve fitting. Additionally, a group additivity method were employed for estimating the heat capacity values of these two compounds at 298.15 K, which are in good agreement with the values measured in this work. © 2018 International Journal of Thermodynamics. All rights reserved.

引用

页码：153 / 157