Models of the pulsatile hydrodynamics of cerebrospinal fluid flow in the normal and abnormal intracranial system

被引：18
作者：
Cheng, S. [1 ]
Jacobson, E. [2 ]
Bilston, L.E. [1 ]
机构：
[1] Prince of Wales Medical Research Institute, University of New South Wales, Randwick 2031, Cnr Barker Street and Easy Street
[2] St George Hospital, Kogarah, NSW
来源：
Computer Methods in Biomechanics and Biomedical Engineering | 2007年 / 10卷 / 02期
关键词：
Cerebrospinal fluid; Hydrodynamics; Pathological brain; Velocity;
D O I：
10.1080/10255840601124753
中图分类号：
学科分类号：
摘要：
Images obtained from magnetic resonance imaging have helped to ascertain that both the cerebrospinal fluid (CSF) and brain move in a pulsatile manner within the cranium. However, these images are not able to reveal any quantitative information on the physiological forces that are associated with pulsatile motion. Understanding both the pressure and velocity flow field of CSF in the ventricles is important to help understand the mechanics of hydrocephalus. Four separate fluid structure interaction models of the ventricular system in the sagittal plane were created for this purpose. The first model was of a normal brain. The second and third models were pathological brain models with aqueductal stenosis at various locations along the fluid pathway. The fourth model was of a hydrocephalic brain. Results revealed the hydrodynamics of CSF pulsatile flow in the ventricles of these models. Most importantly, it has also revealed the different changes in CSF pulsatile hydrodynamics caused by the various locations of fluid flow obstructions. © 2007 Taylor & Francis.
引用
收藏
页码：151 / 157
页数：6
相关论文
共 22 条
  • [1] Bergsneider M., Evolving concepts of cerebrospinal fluid physiology, Neurosurg. Clin. N. Am, 36, 4, pp. 631-638, (2001)
  • [2] Bering E.A., Circulation of the cerebrospinal fluid: Demonstration of the choroid plexuses as the generator of the force for flow of fluid and ventricular enlargement, J. Neurosurg, 19, pp. 405-413, (1962)
  • [3] Bhadelia R.A., Bogdan A.R., Kaplan R.F., Wolpert S.M., Cerebrospinal fluid pulsation amplitude and its quantitative relationship to cerebral blood flow pulsations: A phase-contrast MR flow imaging study, Neuroradiology, 39, pp. 258-264, (1997)
  • [4] Bradley W.C., Whittemore A.R., Kortman K.E., Watanabe A.S., Homyak M., Teresi L.M., Davis S.J., Marked cerebrospinal fluid void. Indicator of successful shunt in patients with suspected normal pressure hydrocephalus, Radiology, 178, pp. 459-466, (1991)
  • [5] Cheng S., Bilston L.E., Unconfined compression of white matter, J. Biomech, (2005)
  • [6] DuBoulay G., O'Connell J., Currie J., Bostick T., Verity R., Further investigations on pulsatile movements in the cerebrospinal fluid pathways, Acta Radiol. Diagn, 13, pp. 496-523, (1972)
  • [7] Egnor M., Zheng L., Rosiallo A., Gutman F., Davis R., A model of pulsations in communicating hydrocephalus, Pediatr. Neurosurg, 36, pp. 281-303, (2002)
  • [8] Enzmann D.R., Pelc N.J., Brain motion: Measurement with phasecontrast MR imaging, Radiology, 185, pp. 653-660, (1992)
  • [9] Feinberg D.A., Functional magnetic resonance imaging, Neuroimaging Clin. N. Am, 5, 1, pp. 125-134, (1995)
  • [10] Feinberg D.A., Mark A.S., Human brain motion and cerebrospinal fluid circulation demonstrated with MR velocity imaging, Radiology, 163, pp. 793-799, (1987)
123