Chemical analysis and antihyperglycemic activity of an original extract from burdock root (Arctium lappa)

被引：0

作者：

机构：

[1] [2,Tousch, Didier

[2] Bidel, Luc. P. R.

[3] Cazals, Guillaume

[4] 2,Ferrare, Karine

[5] 1,Leroy, Jeremy

[6] 1,Faucanié, Marie

[7] 1,Chevassus, Hugues

[8] 1,Tournier, Michel

[9] 1,Lajoix, Anne-Dominique

[10] 1,Azay-Milhau, Jacqueline

来源：

Azay-Milhau, Jacqueline (jacqueline.milhau@univ-montp1.fr) | 1600年 / American Chemical Society卷 / 62期

关键词：

In the present study, we obtained a dried burdock root extract (DBRE) rich in caffeoylquinic acids derivatives. We performed the chemical characterization of DBRE and explored its antihyperglycemic potential in both in vitro and in vivo experiments. Chemical analysis of DBRE using LC-MS and GC-MS revealed the presence of a great majority of dicaffeoylquinic acid derivatives (75.4%) of which 1,5-di-O-caffeoyl-4-O-maloylquinic acid represents 44% of the extract. In the in vitro experiments, DBRE is able to increase glucose uptake in cultured L6 myocytes and to decrease glucagon-induced glucose output from rat isolated hepatocytes together with a reduction of hepatic glucose 6-phosphatase activity. DBRE did not increase insulin secretion in the INS-1 pancreatic β-cell line. In vivo, DBRE improves glucose tolerance both after intraperitoneal and oral subchronic administration. In conclusion, our data demonstrate that DBRE constitutes an original set of caffeoylquinic acid derivatives displaying antihyperglycemic properties. © 2014 American Chemical Society;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Journal article (JA)

引用

共 50 条

[1] Chemical Analysis and Antihyperglycemic Activity of an Original Extract from Burdock Root (Arctium lappa)
Tousch, Didier
Bidel, Luc. P. R.
Cazals, Guillaume
Ferrare, Karine
Leroy, Jeremy
Faucanie, Marie
Chevassus, Hugues
Tournier, Michel
Lajoix, Anne-Dominique
Azay-Milhau, Jacqueline
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2014, 62 (31) : 7738 - 7745
[2] Chemical analysis and antihyperglycemic activity of an original extract from burdock root (arctium lappa)
Azay-Milhau, J. (jacqueline.milhau@univ-montp1.fr), 1600, American Chemical Society (62):
[3] Histopathological Evaluation of Burdock (Arctium lappa) Root Hydroalcoholic Extract on Wound Healing
Ghorat, Fereshteh
Azizkhani, Mohammad
Naji, Shahriar
Ranjbary, Ali Ghorbani
Doostishoar, Farzad
IRANIAN RED CRESCENT MEDICAL JOURNAL, 2017, 19 (01)
[4] Effect of Arctium lappa (burdock) extract on canine dermal fibroblasts
Pomari, Elena
Stefanon, Bruno
Colitti, Monica
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2013, 156 (3-4) : 159 - 166
[5] CHEMICAL NATURE OF A DESMUTAGENIC FACTOR FROM BURDOCK (ARCTIUM-LAPPA LINNE)
MORITA, K
NISHIJIMA, Y
KADA, T
AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1985, 49 (04): : 925 - 932
[6] Analysis of Functional Components of Burdock (Arctium lappa root) Standard Water Extract and its Aphrodisiac Effect in Experimental Rats
Ren, Guo-qing
Luan, Xiao-ning
Dou, De-qiang
JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, 2020, 42 (01): : 94 - 102
[7] Extraction of inulin from Burdock root (Arctium lappa) using high intensity ultrasound
Milani, Elnaz
Koocheki, Arash
Golimovahhed, Q. Ali.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 2011, 46 (08): : 1699 - 1704
[8] Antidiabetic Properties of the Root Extracts of Dandelion (Taraxacum officinale) and Burdock (Arctium lappa)
Zolotova, Daria
Teterovska, Renate
Bandere, Dace
Lauberte, Liga
Niedra, Santa
PLANTS-BASEL, 2024, 13 (07):
[9] Mechanistic insights on burdock (Arctium lappa L.) extract effects on diabetes mellitus
Mondal, Shakti Chandra
Eun, Jong-Bang
FOOD SCIENCE AND BIOTECHNOLOGY, 2022, 31 (08) : 999 - 1008
[10] Silver and gold nanoparticles biosynthesized by aqueous extract of burdock root, Arctium lappa as antimicrobial agent and catalyst for degradation of pollutants
Thi Thanh-Ngan Nguyen
Thanh-Truc Vo
Bich Ngoc-Huong Nguyen
Dinh-Truong Nguyen
Van-Su Dang
Chi-Hien Dang
Thanh-Danh Nguyen
Environmental Science and Pollution Research, 2018, 25 : 34247 - 34261

← 1 2 3 4 5 →