The influence of Ni-Al interaction energy from the first layer to the fourth layer on the ordering behavior of Ni75Al14Mo11 alloy atoms and the precipitation of γ' phase was investigated by the microscopic phase-field kinetic model. The results show that as the first Ni-Al interaction energy increases, the ordering and the clustering degree of Al and Mo atoms increase. As the second Ni-Al interaction energy increases, the ordering and the clustering degree of Al and Mo atoms decrease. As the third Ni-Al interaction energy increase, the degree and speed of the ordering and the clustering of Al and Mo atoms increase. Compared with the early process, the larger atomic interaction in the later precipitation process has less impact on the Mo atoms. And the influence of the fourth Ni-Al interaction energy is the same with the second one. The increase of the first and the third Ni-Al interaction energy promotes the generation of γ' phase, and the volume fraction increases, while the influences of the second and the fourth Ni-Al interatomic energy on γ' phase are contrast to those of the first and the third ones. ©, 2015, Zhongguo Youse Jinshu Xuebao/Chinese Journal of Nonferrous Metals. All right reserved.