Synthesis and antimicrobial activity of dimethyl (2-cyanophenylamino) (substituted aryl) methyl phosphonates

被引：0

作者：

Reddy, G. Chandra Sekhar ^{[1
]}

Kumar, B. Siva ^{[1
]}

Sankar, A. Uma Ravi ^{[1
]}

Reddy, M. Veera Narayana ^{[1
]}

Reddy, C. Suresh ^{[1
]}

机构：

[1] Department of Chemistry Sri Venkateswara University

来源：

Journal of the Korean Chemical Society | 2008年 / 52卷 / 06期

关键词：

2-amino benzonitrile; Antimicrobial activity; Dimethylphosphite; Kabachnic-fields reaction; α-Aminophosphonic acid esters;

D O I：

10.5012/jkcs.2008.52.6.657

中图分类号：

学科分类号：

摘要：

A new class of α-aminophosphonic acid esters (4a-I) have been synthesized by three component one-pot reaction with equimolar quantities of 2-amino benzonitrile (1), dimethylphosphite (3) and various aldehydes (2a-I) in dry toluene at reflux conditions via Kabachnic-Fields reaction in high yields (74-85%). The structure of title compounds has been established by elemental, IR, 1H, 13C, 31P and Mass spectral analysis. They were found to possess significant antimicrobial activity.

引用

页码：657 / 662

页数：5

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