Quartz crystal microbalance with dissipation monitoring: A powerful tool for bionanoscience and drug discovery

被引：0
作者：
Campos, J. [1 ,2 ]
Jiménez, C. [1 ]
Trigo, C. [1 ,2 ]
Ibarra, P. [1 ,2 ]
Rana, Deepti [3 ]
Thiruganesh, R. [4 ]
Ramalingam, Murugan [3 ,5 ]
Haidar, Z.S. [1 ,2 ,6 ]
机构：
[1] BioMATX, Facultad de Odontología, Universidad de los Andes, Mons. Álvaro del Portillo 12.455, Las Condes, Santiago
[2] Plan de Mejoramiento Institucional (PMI) en Innovación-I+ D +I, Universidad de los Andes, Mons. Álvaro del Portillo 12.455, Las Condes, Santiago
[3] Centre for Stem Cell Research (CSCR), A Unit of Institute for Stem Cell Biology and Regenerative Medicine-Bengaluru, Christian Medical College Campus, Vellore
[4] College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan
[5] WPI-Advanced Institute for Materials Research, Tohoku University, Sendai
[6] Centro de Investigación Biomédica, (CIB), Facultad de Medicina, Universidad de Los Andes, Mons. Álvaro del Portillo 12.455, Las Condes, Santiago
来源：
Journal of Bionanoscience | 2015年 / 9卷 / 04期
关键词：
Bionanoscience; Biopolymer; Drug discovery; Nanoarchitecture; QCM-D; Viscoelasticity;
D O I：
10.1166/jbns.2015.1310
中图分类号：
学科分类号：
摘要：
The quartz crystal microbalance-dissipation (QCM-D) is a simple, high-resolution and mass-sensing technique, based on the piezoelectric effect. Its importance rely in the ability to simultaneiously measure both the frequency and dissipation, where the former relates to mass and the later relates to viscoelasticity. The past decade has witnessed an explosive growth in the application of the QCM-D technique to the study of a wide range of molecular systems; protein, lipids, cells, DNA, enzymes, pathogens, biopolymer multi-layer build-up, in ng/cm2, to list a few. This review focuses on recent critical insights and applications in bionanoscience; mainly associated with conformational changes in nano-architecture of biomaterials and drug discovery. copyright © 2015 American Scientific Publishers.
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页码：249 / 260
页数：11
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