Development of fluorescent glucose probes for in vivo diagnostics

被引：0

作者：

Yamada, Katsuya ^{[1
]}

机构：

[1] Department of Physiology, Hirosaki University Graduate School of Medicine, Hirosaki

来源：

Transactions of Japanese Society for Medical and Biological Engineering | 2014年 / 52卷

关键词：

Imaging; Probe; Tumor;

D O I：

10.11239/jsmbe.52.SY-50

中图分类号：

学科分类号：

摘要：

Mammalian cells utilize glucose as an essential fuel, taking it up in a stereoselective manner through glucose transporters (GLUTs), whereby only D-, but not L-, glucose is recognized. Cellular uptake of D-glucose through GLUTs can be monitored by 2-NBDG, a widely used D-glucose analogue emitting green fluorescence. For evaluating the stereoselectivity of the uptake more precisely, we have developed 2-NBDLG, the first commercially available fluorescent L-glucose analogue (fLG), as a negative control substrate for 2-NBDG. In the present study, I introduce some unique features of 2-NBDLG, when applied to mammalian cells as well as its unexpected turn. © 2014, Japan Soc. of Med. Electronics and Biol. Engineering. All rights reserved.

引用

页码：SY / 50

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