A study of the relationship between MICA gene and systemic lupus erythematosus

被引：0

作者：

Ban, Guihong ^{[1
]}

Chu, Jiayou ^{[1
]}

Mao, Changzhi ^{[1
]}

Yang, Zhaoqing ^{[1
]}

Xu, Shaobin ^{[1
]}

Chu, Zhengtao ^{[1
]}

Huang, Xiaoqin ^{[1
]}

Zhang, Sizhong ^{[1
]}

机构：

[1] Department of Genetics, Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming, Yunnan 650118, China

来源：

Chinese Journal of Medical Genetics | 2002年 / 19卷 / 04期

关键词：

Conformations - DNA - Genes - Patient monitoring;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Objective: To investigate the relationship between major histocompatibility complex class I chain-related A(MICA) gene and systemic lupus erythematosus (SLE). Methods: The alleles and frequencies of exons 4 and 5 of MICA gene were determined in 70 cases of SLE and 152 controls of Yunnan Hans by STR genotyping, polymerase chain reaction, single strand conformation polymorphism and bidirection DNA sequencing. Results: Five alleles of exon 5 and 10 alleles of exon 4 were found in this study. The frequency of each allele was determined in patients and controls. There was no significant difference between the two groups in exons 4 and 5 of MICA gene. Conclusion: Exons 4 and 5 of MICA were not related to SLE in Yunnan Hans.

引用

页码：298 / 301