The research on the material of hyaluronic acid, collagen and poly (ethylene glycol) diacrylate composite hydrogel

被引：0
|
作者：
Yuan, Jing [1 ]
Qiu, Lipeng [1 ]
Chen, Jinghua [1 ]
机构：
[1] School of Pharmaceutical Science, Jiangnan University, Wuxi
来源：
Gongneng Cailiao/Journal of Functional Materials | 2015年 / 46卷 / 15期
关键词：
Collagen; Hyaluronic acid; Hydrogel; Poly (ethylene glycol) diacrylate;
D O I：
10.3969/j.issn.1001-9731.2015.15.010
中图分类号：
学科分类号：
摘要：
Aiming at the brittleness of hyaluronic acid (HA) and collagen (Col) hydrogels in mechanical properties, this work was to prepare a composite hydrogel with biocompatibility and high strength by two-step cross-linking method. Hydrogels with different weight percent of HA and constant Col and poly (ethylene glycol) Diacrylate were obtained to tune the physical and chemical properties. Subsequently, L-lysine was used to modify the hydrogels. The SEM results show the honeycomb morphology and the pore size of the ternary hydrogel ranges from 80-180 μm. When the concentration of L-lysine is 40 mmol/L, the comperssion modulus reaches 414 kPa which is 19 times of non-modified hydrogels. Cell toxicity and implantation experiments indicate that the extracts of hydrogel has no obvious inhibitory effect on MC 3T3-E1 cells, and the slight immunological rejection on mice. This kind of composite hydrogel has great potential in cartilage repair. ©, 2015, Journal of Functional Materials. All right reserved.
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页码：15052 / 15057
页数：5
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