Advances in smart biomaterials that modulate the bone microenvironment to promote bone defect repair in diabetes mellitus

被引：0

作者：

Wang, Ruideng ^{[1
,2
,3
,3
]}

He, Xi ^{[3
,3
]}

Su, Shilong ^{[1
,2
]}

Bai, Jinwu ^{[1
,2
]}

Xiang, Qian ^{[1
,2
]}

Liu, Haifeng ^{[3
]}

Zhou, Fang ^{[1
,2
]}

机构：

[1] Department of Orthopedics, Peking University Third Hospital, Beijing

[2] Engineering Research Center of Bone and Joint Precision Medicine, Beijing

[3] Key Laboratory for Biomechanics and Mechanobiology (Beihang University) of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing

来源：

Smart Materials in Medicine | 2024年 / 5卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Biomaterial; Bone repair; Diabetes mellitus; Diabetic bone microenvironment; Inflammation; Oxidative stress;

D O I：

10.1016/j.smaim.2024.07.002

中图分类号：

学科分类号：

摘要：

Diabetes mellitus (DM) is a chronic metabolic disorder that can affect the balance of bone metabolism and bone microenvironment, leading to impaired fracture healing. There are several underlying mechanisms which contributing to the impaired diabetic bone microenvironment such as hyperglycemia, the production of advanced glycation end products (AGEs), inflammation, and oxidative stress, etc. Recent studies have achieved great progress in developing novel smart biomaterials in improving the diabetic bone microenvironment to promote diabetic fracture healing. In this paper, we reviewed the mechanisms on DM-induced impaired fracture healing. Meanwhile, we also summarized the smart biomaterials used to improve the local microenvironment of diabetic fractures healing, which provides a novel perspective for the future treatment of fractures in diabetic patients. © 2024 The Authors

引用

页码：359 / 372

页数：13