Preparation and Controlled Release Behavior of Sodium Alginate-g-Polyacrylamide/Graphene Oxide Composite Hydrogel

被引：0

作者：

Shao Y. ^{[2
]}

Wu C. ^{[1
,2
]}

Cheng C. ^{[2
]}

Li C. ^{[2
]}

Zhang X. ^{[2
]}

Zheng Y. ^{[2
]}

Wu S. ^{[2
]}

机构：

[1] Key Laboratory of Biologic Resources Protection and Utilization of Hubei Province, Enshi

[2] College of Chemistry and Environmental Engineering, Hubei University of Nationalities, Enshi

来源：

Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering | 2018年 / 34卷 / 04期

关键词：

Composite hydrogel; Controlled release; Graphene oxide; Swelling;

D O I：

10.16865/j.cnki.1000-7555.2018.04.018

中图分类号：

学科分类号：

摘要：

Sodium alginate-g-polyacrylamide/ graphene oxide(NaAlg-g-PAAm/GO) composite hydrogel was prepared by solution polymerization with alginate, acrylamide as monomer, graphene oxide as raw material. The structure and morphology of composite hydrogel were characterized by Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The mass fraction of GO increases from 0.6% to 3.2% and the swelling ratio (SR) decreases from 37% to 21%. The effect of cations on the swelling of hydrogels is as follow: Fe3+>Ca2+>K+. In order to imitate the simulated gastric cavity and intestinal environment, using 5-fluorouracil (5-FU) as model for anticancer drug, the controlled release behavior of composite hydrogel was investigated in buffer solution of pH=1.2 and pH=7.4. The experimental results show that the cumulative release (84%) of hydrogel in pH=7.4 buffer solution is significantly higher than that in the solution of pH=1.2, so this kind of hydrogel is expected to become carrier of targeted drug release. © 2018, Editorial Board of Polymer Materials Science & Engineering. All right reserved.

引用

页码：104 / 109

页数：5

共 17 条

[1]

Meng F.H., Zhong Z.Y., Feijen J., Stimuli-responsive polymersomes for programmed drug delivery, Biomacromolecules, 10, pp. 197-209, (2009)

[2]

Kost J., Horbett T.A., Ratner B.D., Et al., Glucose-sensitive membranes containing glucose-oxidase-activity, swelling, and permeability studies, Biomed. Mater. Res., 19, pp. 1117-1133, (1985)

[3]

Bhattarai N., Gunn J., Zhang M.Q., Chitosan-based hydrogels for controlled, localized drug delivery, Adv. Drug Deliv. Rev., 62, pp. 83-99, (2010)

[4]

Ispas-Szabo P., Ravenelle F., Hassan I., Et al., Structure properties relationship in cross-linked high-amylose starch for use in controlled drug release, Carbohydr. Res., 323, pp. 163-175, (2000)

[5]

Gupta K.C., Kumar M.N.V.R., Drug release behavior of beads and microgranules of chitosan, Biomaterials, 21, pp. 1115-1119, (2000)

[6]

Krishnaiah Y.S.R., Satyanarayana V., Kumar B.D., Et al., In vitro drug release studies on guar gum-based colon targeted oral drug delivery systems of 5-fluorouracil, Eur. J. Pharm. Sci., 16, pp. 185-192, (2002)

[7]

Takka S., Acarturk F., Calcium alginate microparticles for oral administration. I: effect of sodium alginate type on drug release and drug entrapment efficiency, J. Microencapsulation, 16, pp. 275-290, (2007)

[8]

Liu M.M., Fan J.Y., Wang K., Et al., Synthesis, characterization, and evaluation of phosphated cross-linked konjac glucomannan hydrogels for colon-targeted drug delivery, Drug Deliv., 14, pp. 397-402, (2007)

[9]

Yang X.Y., Zhang X.Y., Liu Z.F., Et al., High-efficiency loading and controlled release of doxorubicin hydrochloride on graphene oxide, Phys. Chem. C, 112, pp. 17554-17558, (2008)

[10]

Wang J., Liu C.H., Shuai Y., Et al., Controlled release of anticancer drug using graphene oxide as a drug-binding effector in konjac glucomannan/sodium alginate hydrogels, Colloids Surf., B, 113, pp. 223-229, (2014)

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