Analysis of spiral reentry generation mechanisms with cardiac intracellular Ca2+ pocket and temporal Ca2+ burst phenomenon

被引：0

作者：

Arafune, Tatsuhiko ^{[1
]}

Funakubo, Akio ^{[1
]}

Shibata, Nitaro ^{[2
]}

Sakuma, Ichiro ^{[3
]}

Kushiyama, Yasunori ^{[4
]}

Yamazaki, Masatoshi ^{[4
]}

Honjo, Haruo ^{[4
]}

Kamiya, Kaichiro ^{[4
]}

机构：

[1] Division of Electronic and Mechanical Engineering, School of Science and Engineering, Tokyo Denki University

[2] Medical device development and regulation research center, The University of Tokyo

[3] Department of cardiovascular research, Research institute of environmental medicine, Nagoya University

来源：

Transactions of Japanese Society for Medical and Biological Engineering | 2014年 / 52卷

关键词：

Intracellular calcium; Optical mapping; Spiral reentry;

D O I：

10.11239/jsmbe.52.O-408

中图分类号：

学科分类号：

摘要：

Ventricular tachyarrhythmia or ventricular fibrillation. However it was still unknown about Ca2+ mechanisms on the condition of 2D/3D cardiac tissue structure. We developed Vm/Ca2+ dual mapping and precisely registration two signals systems as previously reported, and measured and analyzed Vm/ Ca2+ dynamics during initiated VT to VF changes. Langendorff perfused rabbit heart was stained with Rhod-2 and Rh237 simultaneously. Vm and Ca2+ signal were split by dichroic mirror and recorded as 512 * 512 pixels, 250 fps by two high speed cameras. VT were initiated by cross-field stimulation with S1-S2 protocol. In the episodes of transition VT to VF, Ca2+ sinkhole like pocket area and extremely increased Ca2+ signal (Ca2+ burst) were confirmed and then wave breakup on membrane potential signals and spiral reentry were generated. © 2014, Japan Soc. of Med. Electronics and Biol. Engineering. All rights reserved.

引用

页码：O / 408