Insights into 'fermentonomics': Evaluation of volatile organic compounds (VOCs) in human disease using an electronic 'e-nose'

被引：37

作者：

Arasaradnam R.P. ^{[1
,2
]}

Quraishi N. ^{[2
]}

Kyrou I. ^{[1
]}

Nwokolo C.U. ^{[2
]}

Joseph M. ^{[4
]}

Kumar S. ^{[1
]}

Bardhan K.D. ^{[1
,3
]}

Covington J.A. ^{[4
]}

机构：

[1] Warwick Medical School, University of Warwick

[2] University Hospital Coventry

[3] Rotherham General Hospital

[4] School of Engineering

来源：

Journal of Medical Engineering and Technology | 2011年 / 35卷 / 02期

关键词：

Diabetes; Electronic nose; Fermentome; Inflammatory bowel disease; Volatile organic compounds;

D O I：

10.3109/03091902.2010.539770

中图分类号：

学科分类号：

摘要：

Detection of volatile organic compounds (VOCs) is a common requirement in industry for which numerous methods are available. The electronic nose (e-nose) is an example. Rather than individual chemicals, the e-nose recognizes the 'aroma fingerprint' created by the collection of VOCs in samples, comparable to the human nose. We report on a novel application for gastrointestinal and metabolic medicine, and compare its results to mass spectrometry. Fermentation of undigested foods in the large bowel by its resident bacteria results in the creation of several chemicals including volatile gases that influence colonic and metabolic health. Using urine samples, preliminary results indicate the ability of the e-nose to distinguish between controls and those with inflammatory bowel disease or diabetes (separation rate of ∼97). This emphasizes the different patterns of fermentation. Our term 'fermentonomics' describes the investigation and analysis of the fermentome by such non-invasive means. Such an approach has potentially wide application in medicine. © 2011 Informa UK, Ltd.

引用

页码：87 / 91

页数：4

共 8 条

[1]

Diggle S.P., Gardner A., West S.A., Griffin A.S., Evolutionary theory of bacterial quorum sensing: When is a signal not a signal?, Philosophical Transactions of the Royal Society B, 362, pp. 1241-1249, (2007)

[2]

Arasaradnam R.P., Pharaoh M., Williams G., Nwokolo C., Bardhan K.D., Kumar S., Colonic fermentation - More than meets the nose, Medical Hypotheses, 73, pp. 753-756, (2009)

[3]

Marchesi J.R., Holmes E., Khan F., Kockhar S., Scanlan P., Shanahan F., Et al., Rapid and non-invasive metabonomic characterisation of inflammatory bowel disease, Journal of Proteome Research, 6, pp. 546-551, (2007)

[4]

Ley R.E., Turnbaugh P.J., Klein S., Gordon J.I., Microbial ecology: Human gut microbes associated with obesity, Nature, 21, 444, pp. 1022-1023, (2006)

[5]

Persaud K., Dodd G., Analysis of discrimination mechanisms in the mammalian olfactory system using a model nose, Nature, 299, pp. 352-355, (1982)

[6]

Perce T.M., Schiffman S.S., Nagle T., Gardner J.W., Handbook of Machine Olfaction: Electronic Nose Technology, (2003)

[7]

Arshak K.E., Moore E., Lyons M., Harris J., Clifford S., A review of gas sensors employed in electronic nose applications, Sensor Review, 24, pp. 181-198, (2004)

[8]

Wilson P.F., Freeman C.G., McEwan M.J., Reactions of small hydrocarbons with H3O+,O2+ and NO+ ions, International Journal of Mass Spectrometry, 229, pp. 143-149, (2003)

← 1 →