Biocompatibility evaluation of piezoelectric materials through cytotoxicity test

被引：1

作者：

Uetsuji, Yasutomo ^{[1
]}

Ueda, Takahiro ^{[1
]}

Hwang, Hwishim ^{[2
]}

Hirano, Yoshiaki ^{[3
]}

Tsuchiya, Kazuyoshi ^{[4
]}

Nakamachi, Eiji ^{[5
]}

机构：

[1] Dept. of Mech. Eng., Osaka Inst. of Tech., Asahi-ku, Osaka

[2] Graduate School of Eng., Osaka Inst. of Tech., Asahi-ku, Osaka

[3] Dept. of Appl. Chem., Osaka Inst. of Tech., Asahi-ku, Osaka

[4] Dept. of Precision Eng., Tokai Univ., Kitakinme, Hiratuka

[5] Dept. of Biomedical Eng., Doshisha Univ., Tatara, Kyotanabe

来源：

Zairyo/Journal of the Society of Materials Science, Japan | 2008年 / 57卷 / 09期

关键词：

Biocompatibility; Biomaterial; Cytotoxicity; Perovskite-type oxides; Piezoelectric material;

D O I：

10.2472/jsms.57.899

中图分类号：

学科分类号：

摘要：

Biocompatible piezoelectric materials are becoming increasingly important for actuators and sensors in medical devices. In this paper, we highlighted on some perovskite-type oxides MgSiO3, CaSiO3 and CaTiO 3 of biocompatible piezoelectric materials discovered by first-principles calculation in our previous studies. In order to verify their biocompatibility, the cytotoxicity of similar oxides with the same components was examined as comparing with typical perovskite-type oxides Pb (Zr, Ti)O 3 and BaTiO3. The fibroblast (L929) cells were cultured during 7days and the effect of materials was evaluated by relative proliferation ratio and doubling time. As a result, it was recognized that MgSiO3 and CaTiO3 has the higher biocompatibility. On the other hand, CaSiO3 and Pb (Zr, Ti) O3 shows the strong toxicity and they can't be applied to medical devices. © 2008 The Society of Materials Science.

引用

页码：899 / 904

页数：5

共 12 条

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