Dopant-assisted atmospheric pressure photoionization of patulin in apple juice and apple-based food with liquid chromatography-tandem mass spectrometry

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[1] Zhang, Kai
[2] Wong, Jon W.
[3] Mai, Huy
[4] Trucksess, Mary W.
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Zhang, Kai (kai.zhang@fda.hhs.gov) | 1600年 / American Chemical Society卷 / 62期
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A dopant-assisted atmospheric pressure photoionization (APPI) with liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed to determine patulin in apple juice and apple-based food. Different dopants; dopant flow rates; and LC separation conditions were evaluated. Using toluene as the dopant; the LC-APPI-MS/MS method achieved a linear calibration from 12.5 to 2000 μg/L (r2 > 0.99). Matrix-dependent limits of quantitation (LOQs) were from 8 μg/L (solvent) to 12 μg/L (apple juice). [13C]-Patulin-fortified apple juice samples were directly analyzed by the LC-APPI-MS/MS method. Other apple-based food was fortified with [13C]-patulin; diluted using water (1% formic acid); centrifuged; and filtered; followed by LC-APPI-MS/MS analysis. In clear apple juice; unfiltered apple cider; applesauce; and apple-based baby food; average recoveries were 101 ± 6% (50 μg/kg); 103 ± 5% (250 μg/kg); and 102 ± 5% (1000 μg/kg) (av ± SD; n = 16). Using the suggested method; patulin was detected in 3 of 30 collected market samples with concentrations ranging from 13C]-patulin allowed quantitation using solvent calibration standards with satisfactory precision and accuracy. © This article not subject to U.S. Copyright. Published 2014 by the American Chemical Society;
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