Analysis of metabolic oscillation processes in Saccharomyces cerevisiae

被引：0
|
作者：
Pan D. [1 ,2 ]
Shi H. [2 ]
Yuan D. [2 ]
Xiu Z. [1 ]
机构：
[1] School of Life Science and Biotechnology, Dalian University of Technology, Dalian, 116024, Liaoning
[2] Chemical Control Technology Key Laboratory of Liaoning Province, Shenyang University of Chemical Technology, Shenyang, 110142, Liaoning
来源：
Huagong Xuebao/CIESC Journal | 2017年 / 68卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Bifurcation analysis; Glycolysis; Limit cycle; Nonlinear programming; Oscillation; Systems biology;
D O I：
10.11949/j.issn.0438-1157.20161628
中图分类号：
学科分类号：
摘要：
Oscillation phenomenon is an inherent characteristic in biological systems and plays an important role in many dynamic bioprocesses. In order to explore the certain conditons that could possibly boost a oscillation, the metabolic pathway of the Saccharomyces cerevisiae, glycolysis were researched, and the parameters of mathmatical model was analyzed. Firstly, the simulation results associated the phase diagrams indicated that the model exists sustained oscillations with constant amplitude (limit cycle oscillations). Next, bifurcation analysis approach was used to investigate the infulence of parameters for the system producing oscillations. The results showed that several parameters of the model could lead to oscillations and the range of parameters' value was obtained, which could be applied to direct the manipulation of metabolic oscillations. © All Right Reserved.
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页码：964 / 969
页数：5
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