Nano-indentation device for investigating the mechanics of compliant materials

被引：0
|
作者：
Evans, D.W. [1 ,2 ]
Vavalle, N.A. [1 ,2 ]
De Vita, R. [2 ,4 ]
Rajagopalan, P. [2 ,3 ]
Sparks, J.L. [1 ,2 ]
机构：
[1] [1,Evans, D.W.
[2] 1,Vavalle, N.A.
[3] 2,De Vita, R.
[4] 2,Rajagopalan, P.
[5] 1,Sparks, J.L.
来源：
Sparks, J.L. (jsparks@wakehealth.edu) | 1600年 / Society for Experimental Mechanics Inc.卷 / 53期
关键词：
Biomechanics - Elastic moduli - Hydrogels - Materials testing - Shear strain - Cell culture - Silicones;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Indentation testing has long been used to measure the mechanical properties of a wide range of materials from metals and ceramics to brain tissue and hydrogels. The purpose of this study was to build and validate a Nano-Tissue Indenter (NTI) capable of performing indentation testing on micro-scale structures within the liver's extracellular matrix. Two silicone-based tissue simulant materials were selected with elastic properties similar to hydrogels used for liver cell cultures. Samples of each material formulation, EcoFlex0030 (EF30) and EcoFlex0010 (EF10), were indented with NTI and also tested in unconfined compression to provide benchmark shear moduli. The resulting force and displacement measurements from NTI with resolutions of 300 nN and 700 nm respectively were analyzed using the Pietrement-Troyon model of adhesive contact. Using this method, NTI was able to distinguish a 10 kPa difference in shear modulus between EF30 and EF10 with comparable significance as unconfined compression (p
引用
收藏
页码：217 / 229
相关论文
共 50 条
  • [41] Measurement of PBX elastic modulus by nano-indentation
    Li, Ming
    Lan, Lin-Gang
    Pang, Hai-Yan
    Wen, Mao-Ping
    Jing, Shi-Ming
    Hanneng Cailiao/Chinese Journal of Energetic Materials, 2007, 15 (02): : 101 - 104
  • [42] Response of Viral Shells under Nano-Indentation
    Ivanovska, Irena L.
    de Pablo, Pedro J.
    Miranda, Roberto
    Gibbons, Melissa M.
    Michel, Jean-Philipe
    Wuite, Gijs J. L.
    MacKintosh, Fred C.
    Carrascosa, Jose L.
    Klug, William S.
    Bruinsma, Robijn F.
    Knobler, Charles M.
    Schmidt, Christoph F.
    BIOPHYSICAL JOURNAL, 2009, 96 (03) : 16A - 16A
  • [43] In Situ NANO-Indentation of Round Window Membrane
    Watanabe, Hirobumi
    Lalwani, Anil K.
    Kysar, Jeffrey W.
    MECHANICS OF BIOLOGICAL SYSTEMS AND MATER IALS, VOL 6, 2016, : 17 - 29
  • [44] Effects of elastic-plastic properties of materials on residual indentation impressions in nano-indentation using sharp indenter
    Lee, Jung-Min
    Lee, Chan-Joo
    Lee, Kyung-Hun
    Kim, Byung-Min
    TRANSACTIONS OF NONFERROUS METALS SOCIETY OF CHINA, 2012, 22 : S585 - S595
  • [45] Effects of elastic-plastic properties of materials on residual indentation impressions in nano-indentation using sharp indenter
    Jung-Min LEE
    Chan-Joo LEE
    Kyung-Hun LEE
    Byung-Min KIM
    Transactions of Nonferrous Metals Society of China, 2012, 22(S3) (S3) : 585 - 595
  • [46] Multiscale simulation of the size effect of nano-indentation
    Wang, Zhenqing
    Meng, Qinghua
    Yang, Zengjie
    ADVANCES IN FRACTURE AND DAMAGE MECHANICS XI, 2013, 525-526 : 309 - 312
  • [47] INTEGRATING CAD AND NANO-INDENTATION FOR COMPLEX LITHOGRAPHY
    Xu, Kangmin
    Yang, Seung-Cheol
    Qian, Xiaoping
    PROCEEDINGS OF THE ASME INTERNATIONAL DESIGN ENGINEERING TECHNICAL CONFERENCES AND COMPUTERS AND INFORMATION IN ENGINEERING CONFERENCE 2012, VOL 2, PTS A AND B, 2012, : 439 - 447
  • [48] A Better Understanding of Myelination Using Nano-Indentation
    Hanna, Amgad S.
    Dempsey, Robert
    NEUROSURGERY, 2011, 69 (06) : N10 - N10
  • [49] NANO-INDENTATION METHODOLOGY FOR CARTILAGE QUALITY ASSESSMENT
    Lavet, C.
    Ammann, P.
    OSTEOARTHRITIS AND CARTILAGE, 2016, 24 : S343 - S344
  • [50] Nano-indentation in FCC metals: experimental study
    Amin H. Almasri
    George Z. Voyiadjis
    Acta Mechanica, 2010, 209 : 1 - 9
12345