Peptide derivatives of antibiotics tylosin and desmycosin, protein synthesis inhibitors

被引：0

作者：

Sumbatyan, N.V. ^{[1
]}

Korshunova, G.A. ^{[1
]}

Bogdanov, A.A. ^{[1
]}

机构：

[1] MGU im. M.V. Lomonosova, Moscow, 119992, Russia

来源：

Biokhimiya | 2003年 / 68卷 / 10期

关键词：

Enzyme inhibition - Polypeptides - Synthesis (chemical);

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Biologically active peptide derivatives of 16-member macrolide antibiotics were synthesized as potential probes for the investigation of nascent peptide chain topography in the ribosomal exit tunnel. The tylosin and desmycosin aldehyde groups at the C6 position of the lactone ring were modified by the aminooxyacetyl-L-alanyl-L-alanine methyl ester.

引用

页码：1436 / 1438

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